SCHEMBL7272875

SCHEMBL7272875

Cc1onc(OC2CN3CCC2CC3)c1Cl

nearest known ligand 0.52

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CHRM1 P11229 9/20 0.42
CHRM2 P08172 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7278485 0.99 CHRM1 (0.41) CHRM1CHRM2
SCHEMBL7272311 0.85 CHRM1 (0.44) CHRM1
Hydrochloric Acid SCHEMBL7278417 0.84 CHRM1 (0.43) CHRM1
SCHEMBL7272156 0.83 CHRM1 (0.42) CHRM1
SCHEMBL7278386 0.82 CHRM1 (0.40) CHRM1CHRM2
Hydrochloric Acid SCHEMBL7279918 0.82 CHRM1 (0.41) CHRM1
Hydrochloric Acid SCHEMBL7279593 0.81 CHRM1 (0.44) CHRM1CHRM2
Hydrochloric Acid SCHEMBL7271416 0.81 CHRM1 (0.39) CHRM1CHRM2
SCHEMBL7272053 0.77 CHRM2 (0.42) CHRM1CHRM2
Hydrochloric Acid SCHEMBL7272563 0.76 CHRM2 (0.41) CHRM1CHRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5643923-A TREATMENT OF ANXIETY, COGNITION ACTIVATORS, SENILITY OR ALZHEIMER'S SANKYO COMPANY, LIMITED (JP) 1997-07-01 US claimed
US-5643923-A TREATMENT OF ANXIETY, COGNITION ACTIVATORS, SENILITY OR ALZHEIMER'S SANKYO COMPANY, LIMITED (JP) 1997-07-01 US disclosed
EP-0456519-B1 Piperidyloxy- and quinuclidinyloxy- isoxazole derivatives, their preparation and their therapeutic use SANKYO CO (JP) 1994-07-13 EP disclosed
EP-0456519-A1 Piperidyloxy- and quinuclidinyloxy- isoxazole derivatives, their preparation and their therapeutic use Sankyo Company Limited (JP) 1991-11-13 EP disclosed