Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.58 |
| ▸ | HRH1 | P35367 | 3/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | AOC3 | Q16853 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.41 |
| ▸ | SCN1A | P35498 | 1/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.41 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7272216 | 0.87 | HRH1 (0.60) | HTR2AHRH1TDP1SIGMAR1AOC3 | |
| SCHEMBL3068671 | 0.85 | HRH1 (0.62) | HTR2AHRH1TDP1SIGMAR1AOC3 | |
| SCHEMBL13995351 | 0.79 | AOC3 (0.59) | HTR2AHRH1AOC3KDM4EALDH1A1 | |
| SCHEMBL3068667 | 0.76 | HRH1 (0.60) | HTR2AHRH1TDP1SIGMAR1SLC6A2 | |
| SCHEMBL7274896 | 0.76 | HTR2A (0.55) | HTR2AHRH1SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL7502750 | 0.75 | HRH1 (0.58) | HTR2AHRH1TDP1SIGMAR1AOC3 | |
| SCHEMBL27587669 | 0.74 | HRH1 (0.50) | HTR2AHRH1KDM4EALDH1A1SLC6A2 | |
| SCHEMBL1802493 | 0.74 | HRH1 (1.00) | HTR2AHRH1TDP1SIGMAR1KDM4E | |
| SCHEMBL8096616 | 0.74 | AOC3 (0.58) | HTR2AHRH1TDP1AOC3TAAR1 | |
| SCHEMBL8297797 | 0.74 | HTR2A (0.62) | HTR2AHRH1SIGMAR1AOC3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102531999-B | Amorphous lercanidipine hydrochloride and preparation method thereof | BEIJING SECOND PHARMACEUTICAL CO LTD | 2014-02-26 | — | — | CN | disclosed |
| CN-102558032-B | Amorphous lercanidipine hydrochloride and preparation method thereof | CHINA RESOURCES SAIKE PHARMACEUTICAL CO LTD | 2014-02-26 | — | — | CN | disclosed |
| US-4968832-A | INTERMEDIATES FOR CORONARY DILATORS | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1990-11-06 | — | — | US | disclosed |
| US-4772621-A | Antihypertensive diphenylpropyl aminopropyl ester of 1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylic acid | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1988-09-20 | — | — | US | disclosed |
| US-4705797-A | HYPOTENSIVE AGENTS, VASODILATORS | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1987-11-10 | — | — | US | disclosed |
| EP-0153016-A2 | Asymmetrical diesters of 1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylic acid | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY (CH) | 1985-08-28 | — | — | EP | disclosed |