Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 9/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.49 |
| ▸ | PDE4A | P27815 | 6/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | GRK6 | P43250 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7273670 | 0.85 | PDE3B (0.50) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10333086 | 0.84 | MAPT (0.59) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL11703472 | 0.84 | PDE3B (0.49) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL11634895 | 0.81 | PDE3B (0.49) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10956470 | 0.81 | PDE3B (0.57) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7276255 | 0.81 | PDE3B (0.46) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL11741776 | 0.79 | PDE3B (0.55) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL21969531 | 0.78 | PDE3B (0.65) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL21970119 | 0.78 | MAPT (0.51) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL20703014 | 0.77 | PDE3B (0.54) | PDE3BPDE3APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4954499-A | Pyridazinone derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-09-04 | — | — | US | claimed |
| EP-0327800-B1 | 6-PHENYLDIHYDRO-3(2H)-PYRIDAZINONES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THESE COMPOUNDS | HEUMANN PHARMA GMBH & CO (DE) | 1992-05-27 | — | — | EP | disclosed |
| US-4954499-A | Pyridazinone derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-09-04 | — | — | US | disclosed |
| US-4954501-A | INOTROPIC AGENTS | HEUMANN PHARMA GMBH & CO. (DE) | 1990-09-04 | — | — | US | disclosed |
| EP-0327800-A2 | 6-Phenyldihydro-3(2H)-pyridazinones, process for their preparation and medicines containing these compounds | HEUMANN PHARMA GMBH & CO (DE) | 1989-08-16 | — | — | EP | disclosed |
| EP-0279283-A2 | Pyridazinone derivatives | MERCK PATENT GmbH (DE) | 1988-08-24 | — | — | EP | disclosed |