Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.44 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7878480 | 0.87 | POLB (0.49) | POLBNPSR1MEN1KMT2AGAA | |
| SCHEMBL11163507 | 0.84 | MEN1 (0.58) | POLBNPSR1MEN1KMT2AGAA | |
| SCHEMBL27832205 | 0.84 | NPSR1 (0.50) | POLBNPSR1MEN1KMT2AGAA | |
| SCHEMBL14377773 | 0.81 | SMN1; SMN2 (0.60) | POLBGAASMN1; SMN2 | |
| SCHEMBL14377755 | 0.80 | F2 (0.59) | POLBGAASMN1; SMN2 | |
| SCHEMBL14377732 | 0.79 | GAA (0.51) | POLBNPSR1MEN1KMT2AGAA | |
| SCHEMBL13685284 | 0.78 | POLB (0.53) | POLBNPSR1MEN1KMT2AGAA | |
| SCHEMBL27828383 | 0.78 | GAA (0.55) | POLBNPSR1KMT2AGAAKDM4E | |
| SCHEMBL14376753 | 0.78 | F2 (0.63) | — | |
| SCHEMBL9053712 | 0.77 | POLB (0.60) | POLBNPSR1MEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210545-A2 | Phosphorous containing enzyme inhibitors | MERCK & CO. INC. (US) | 1987-02-04 | — | — | EP | disclosed |
| EP-0209897-A2 | Peptide enzyme inhibitors | MERCK & CO. INC. (US) | 1987-01-28 | — | — | EP | disclosed |
| EP-0209848-A2 | Enzyme inhibitors | MERCK & CO. INC. (US) | 1987-01-28 | — | — | EP | disclosed |