Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.36 |
| ▸ | CHRNG | P07510 | 1/20 | 0.36 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | CHRND | Q07001 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18165458 | 0.88 | CYP1A2 (0.47) | MAPTNPC1RAB9AHSD17B1HPGD | |
| SCHEMBL3724986 | 0.79 | MAPT (0.58) | MAPTNPC1RAB9AHSD17B1HPGD | |
| SCHEMBL17513830 | 0.79 | MAPT (0.58) | MAPTNPC1RAB9AHSD17B1HPGD | |
| SCHEMBL4959346 | 0.77 | MAPT (0.56) | MAPTNPC1RAB9AHSD17B1HPGD | |
| SCHEMBL20444064 | 0.77 | MAPT (0.56) | MAPTNPC1RAB9AHSD17B1HPGD | |
| SCHEMBL20444101 | 0.77 | MAPT (0.56) | MAPTNPC1RAB9AHSD17B1HPGD | |
| SCHEMBL7284288 | 0.76 | MAPT (0.43) | MAPTPOLBCA2 | |
| Hydrochloric Acid SCHEMBL31051373 | 0.76 | MAPT (0.55) | MAPTNPC1RAB9AHSD17B1HPGD | |
| SCHEMBL10887975 | 0.75 | NPC1 (0.53) | MAPTNPC1RAB9AHSD17B1HPGD | |
| SCHEMBL26805001 | 0.75 | MAPT (0.53) | MAPTNPC1RAB9AHSD17B1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0483667-B1 | Cyclic imino derivatives, process for their preparation and drugs containing them | THOMAE GMBH DR K (DE) | 1998-02-04 | — | — | EP | disclosed |
| US-5591769-A | PYRROLIDINE DERIVATIVES; ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1997-01-07 | — | — | US | disclosed |
| US-5541343-A | ANTIAGGLOMERANTS FOR CELLS OR ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |
| EP-0483667-A2 | Cyclic imino derivatives, process for their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1992-05-06 | — | — | EP | disclosed |