Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1F | O60840 | 11/20 | 0.64 |
| ▸ | CACNA1D | Q01668 | 11/20 | 0.64 |
| ▸ | CACNA1S | Q13698 | 11/20 | 0.64 |
| ▸ | CACNA1C | Q13936 | 11/20 | 0.64 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7265800 | 0.90 | CACNA1F (0.58) | CACNA1FCACNA1DCACNA1SCACNA1CADRA1D | |
| SCHEMBL7271893 | 0.90 | CACNA1F (0.66) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL7275064 | 0.90 | CACNA1F (0.61) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL9476160 | 0.88 | CACNA1F (0.67) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL7265084 | 0.87 | CACNA1F (0.66) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL7265098 | 0.87 | CACNA1F (0.58) | CACNA1FCACNA1DCACNA1SCACNA1CMEN1 | |
| SCHEMBL7267141 | 0.85 | CACNA1F (0.63) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL7266718 | 0.84 | CACNA1C (0.55) | CACNA1FCACNA1DCACNA1SCACNA1CADRA1D | |
| SCHEMBL10556213 | 0.84 | CACNA1F (0.58) | CACNA1FCACNA1DCACNA1SCACNA1CADRA1D | |
| SCHEMBL9478573 | 0.83 | CACNA1F (0.64) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237347-B1 | 1,2,3,4-Tetrahydro-6-substituted-4-aryl (or heterocyclo)-3-[(substituted amino)carbonyl]-2-thioxo (or oxo)-5-pyrimidinecarboxylic acids and esters | E.R. Squibb & Sons, Inc. (US) | 1991-06-12 | — | — | EP | disclosed |
| US-4855301-A | 1,2,3,4-Tetrahydro-6-substituted-4-aryl(or heterocyclo)-3-((substituted amino)carbonyl)-2-thioxo (or oxo)-5-pyrimidinecarboxylic acids and esters | E. R. SQUIBB & SONS, INC. (US) | 1989-08-08 | — | — | US | disclosed |
| EP-0237347-A2 | 1,2,3,4-Tetrahydro-6-substituted-4-aryl (or heterocyclo)-3-[(substituted amino)carbonyl]-2-thioxo (or oxo)-5-pyrimidinecarboxylic acids and esters | E.R. Squibb & Sons, Inc. (US) | 1987-09-16 | — | — | EP | disclosed |