⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7274940 | 1.00 | — | — | |
| SCHEMBL10950851 | 0.86 | — | — | |
| SCHEMBL10950846 | 0.86 | — | — | |
| SCHEMBL1075580 | 0.84 | SPHK2 (0.41) | — | |
| SCHEMBL1075578 | 0.84 | SPHK2 (0.41) | — | |
| SCHEMBL11859979 | 0.84 | RECQL (0.33) | — | |
| SCHEMBL11854597 | 0.82 | SPHK2 (0.45) | — | |
| SCHEMBL11862596 | 0.82 | SPHK2 (0.45) | — | |
| SCHEMBL11854593 | 0.82 | SPHK2 (0.45) | — | |
| SCHEMBL11862603 | 0.82 | SPHK2 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0516392-B1 | Naphthyridine derivatives as angiotensin II inhibitors | ASTRAZENECA AB (SE) | 2001-08-29 | — | — | EP | disclosed |
| US-5294620-A | Hypotensive agents or compounds for cardiovascular disorders | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-03-15 | — | — | US | disclosed |
| US-5236937-A | Treating hypertension, congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-08-17 | — | — | US | disclosed |
| CN-1073174-A | Hete rocyclic derivatives | ICI PLC (GB) | 1993-06-16 | — | — | CN | disclosed |
| US-5217976-A | Hypotensive agents, congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-06-08 | — | — | US | disclosed |
| EP-0516392-A2 | Naphthyridine derivatives as angiotensin II inhibitors | ZENECA LIMITED (GB) | 1992-12-02 | — | — | EP | disclosed |
| EP-0499415-A1 | Pyridine and quinoline derivatives, processes for their manufacture and their use as angiotensin II antagonists | ZENECA LIMITED (GB) | 1992-08-19 | — | — | EP | disclosed |
| EP-0135252-A2 | Process for preparing 3-substituted-3-aminonitrile | ELI LILLY AND COMPANY (US) | 1985-03-27 | — | — | EP | disclosed |
| EP-0129408-A2 | (3-alkyl-5-isothiazolyl)ureas | ELI LILLY AND COMPANY (US) | 1984-12-27 | — | — | EP | disclosed |