Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.55 |
| ▸ | BACE1 | P56817 | 2/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 2/20 | 0.46 |
| ▸ | REN | P00797 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 2/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 1/20 | 0.45 |
| ▸ | ACE | P12821 | 2/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8281497 | 0.94 | KLK5 (0.51) | KLK5BACE1ATMCTSLREN | |
| SCHEMBL3036976 | 0.94 | KLK5 (0.51) | KLK5BACE1ATMCTSLREN | |
| SCHEMBL13390560 | 0.94 | KLK5 (0.51) | KLK5BACE1ATMCTSLREN | |
| SCHEMBL7356966 | 0.83 | KLK5 (0.59) | KLK5ATMCTSLRENL3MBTL1 | |
| Hydrochloric Acid SCHEMBL4365127 | 0.82 | BACE1 (0.58) | BACE1 | |
| Hydrochloric Acid SCHEMBL4365118 | 0.82 | BACE1 (0.58) | BACE1 | |
| Hydrochloric Acid SCHEMBL4365123 | 0.82 | BACE1 (0.58) | BACE1 | |
| SCHEMBL6446193 | 0.80 | KLK5 (0.63) | KLK5ATMCTSLCTSSCTSB | |
| SCHEMBL6445261 | 0.80 | KLK5 (0.63) | KLK5ATMCTSLCTSSCTSB | |
| SCHEMBL6444857 | 0.80 | KLK5 (0.63) | KLK5ATMCTSLCTSSCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0361341-A2 | Therapeutics for aids based on inhibitors of HIV protease | MILES INC. (US) | 1990-04-04 | — | — | EP | disclosed |