Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 13/20 | 0.49 |
| ▸ | DRD2 | P14416 | 5/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | KIF11 | P52732 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7267640 | 0.86 | DRD1 (0.53) | DRD1DRD2MAPK1THPOHIF1A | |
| SCHEMBL7274391 | 0.84 | DRD1 (0.54) | DRD1DRD2MAPK1THPOHIF1A | |
| SCHEMBL7266528 | 0.83 | DRD1 (0.47) | DRD1DRD2MAPK1THPOHIF1A | |
| Hydrochloric Acid SCHEMBL7267226 | 0.83 | DRD1 (0.56) | DRD1DRD2MAPK1THPOHIF1A | |
| Hydrochloric Acid SCHEMBL7266803 | 0.82 | DRD1 (0.49) | DRD1DRD2MAPK1THPOHIF1A | |
| SCHEMBL7273401 | 0.82 | DRD1 (0.46) | DRD1DRD2MAPK1THPOHIF1A | |
| SCHEMBL7268165 | 0.81 | DRD1 (0.45) | DRD1DRD2MAPK1THPOHIF1A | |
| SCHEMBL10414549 | 0.81 | DRD1 (0.49) | DRD1DRD2MAPK1THPOHIF1A | |
| SCHEMBL9031324 | 0.78 | DRD1 (0.60) | DRD1DRD2MAPK1THPOHIF1A | |
| Hydrochloric Acid SCHEMBL9031847 | 0.77 | DRD1 (0.59) | DRD1DRD2MAPK1THPOHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0324610-B1 | Thieno[2,3-d]azepine derivatives, process for their preparation and pharmaceutical compositions containing them | LILLY INDUSTRIES LTD (GB) | 1994-04-13 | — | — | EP | disclosed |
| US-4904653-A | Thieno[2,3-O]azepine compounds and CNS affecting use thereof | LILLY INDUSTRIES LIMITED (GB) | 1990-02-27 | — | — | US | disclosed |
| EP-0324610-A2 | Thieno[2,3-d]azepine derivatives, process for their preparation and pharmaceutical compositions containing them | LILLY INDUSTRIES LIMITED (GB) | 1989-07-19 | — | — | EP | disclosed |