Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 14/20 | 0.51 |
| ▸ | DRD2 | P14416 | 7/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | DRD5 | P21918 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | THPO | P40225 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | GPR183 | P32249 | 1/20 | 0.41 |
| ▸ | APLNR | P35414 | 1/20 | 0.41 |
| ▸ | GLP1R | P43220 | 1/20 | 0.41 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7268604 | 0.99 | DRD1 (0.53) | DRD1DRD2HSD17B10DRD5CYP2D6 | |
| SCHEMBL7275785 | 0.84 | DRD1 (0.41) | DRD1DRD2HSD17B10DRD5CYP2D6 | |
| Hydrochloric Acid SCHEMBL7294530 | 0.83 | DRD1 (0.58) | DRD1DRD2HSD17B10DRD5CYP2D6 | |
| Hydrochloric Acid SCHEMBL7301244 | 0.81 | DRD1 (0.57) | DRD1DRD2HSD17B10DRD5CYP2D6 | |
| Hydrochloric Acid SCHEMBL7299250 | 0.81 | DRD1 (0.56) | DRD1DRD2HSD17B10DRD5CYP2D6 | |
| SCHEMBL7276967 | 0.80 | DRD1 (0.53) | DRD1DRD2HSD17B10DRD5CYP2D6 | |
| Hydrochloric Acid SCHEMBL7300699 | 0.79 | DRD1 (0.55) | DRD1DRD2HSD17B10DRD5CYP2D6 | |
| SCHEMBL7266679 | 0.79 | DRD1 (0.54) | DRD1DRD2HSD17B10DRD5CYP2D6 | |
| SCHEMBL7275194 | 0.78 | DRD1 (0.53) | DRD1DRD2HSD17B10DRD5CYP2D6 | |
| SCHEMBL7268165 | 0.77 | DRD1 (0.45) | DRD1DRD2HSD17B10DRD5CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0324610-B1 | Thieno[2,3-d]azepine derivatives, process for their preparation and pharmaceutical compositions containing them | LILLY INDUSTRIES LTD (GB) | 1994-04-13 | — | — | EP | disclosed |
| US-4904653-A | Thieno[2,3-O]azepine compounds and CNS affecting use thereof | LILLY INDUSTRIES LIMITED (GB) | 1990-02-27 | — | — | US | disclosed |
| EP-0324610-A2 | Thieno[2,3-d]azepine derivatives, process for their preparation and pharmaceutical compositions containing them | LILLY INDUSTRIES LIMITED (GB) | 1989-07-19 | — | — | EP | disclosed |