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Sugi Predict / Compounds / SCHEMBL7276475

SCHEMBL7276475

SCHEMBL7276475

CC(=O)Nc1ccc(-c2ccccc2)n(CC(=O)NC(I)(C(C)C)C(O[Si](C)(C)C(C)(C)C)C(F)(F)F)c1=O.c1cc2cc-2c1

nearest known ligand 0.53

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ ELANE P08246 20/20 0.53
▸ CTRC Q99895 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7282740 0.89 ELANE (0.46) ELANECTRC
SCHEMBL7276477 0.82 ELANE (0.60) ELANECTRC
SCHEMBL7276943 0.74 ELANE (0.68) ELANECTRC
SCHEMBL9011925 0.73 ELANE (0.94) ELANECTRC
SCHEMBL7281282 0.72 ELANE (0.51) ELANECTRC
SCHEMBL7276466 0.72 ELANE (0.64) ELANECTRC
SCHEMBL7301001 0.72 ELANE (0.56) ELANECTRC
SCHEMBL7284265 0.72 ELANE (0.50) ELANECTRC
SCHEMBL7283007 0.72 ELANE (0.49) ELANECTRC
SCHEMBL7303022 0.70 ELANE (0.42) ELANECTRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0509769-A2 Heterocyclic amides having HLE inhibiting activity ZENECA LIMITED (GB) 1992-10-21 — — EP disclosed