Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 4/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | DRD2 | P14416 | 3/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.38 |
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.38 |
| ▸ | DPP4 | P27487 | 5/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.38 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7272892 | 0.88 | DRD3 (0.39) | DRD3KCNH2DRD2S1PR1DPP4 | |
| SCHEMBL7284086 | 0.88 | S1PR1 (0.48) | DRD3KCNH2DRD2GPR119S1PR1 | |
| SCHEMBL7281015 | 0.84 | S1PR1 (0.43) | DRD3KCNH2DRD2S1PR1CYP11B1 | |
| Hydrochloric Acid SCHEMBL7273081 | 0.81 | S1PR1 (0.38) | DRD3KCNH2DRD2S1PR1DPP4 | |
| SCHEMBL7275777 | 0.80 | DRD3 (0.48) | DRD3KCNH2DRD2CYP11B1CYP11B2 | |
| SCHEMBL7273305 | 0.79 | KCNH2 (0.39) | DRD3KCNH2DRD2S1PR1CYP11B1 | |
| SCHEMBL7272166 | 0.77 | S1PR1 (0.39) | DRD3KCNH2DRD2S1PR1EGLN2 | |
| SCHEMBL7283860 | 0.77 | S1PR1 (0.49) | DRD3DRD2S1PR1PKM | |
| SCHEMBL7275335 | 0.77 | DPP4 (0.40) | DRD3KCNH2DRD2S1PR1DPP4 | |
| SCHEMBL7274980 | 0.76 | KDM4E (0.40) | DRD3KCNH2DRD2S1PR1CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5852192-A | Cyclic urea derivatives, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1998-12-22 | — | — | US | disclosed |
| US-5650424-A | ANTIAGGLOMERANTS USING IMIDAZOLIDINDIONES | DR. KARL THOMAE GMBH (DE) | 1997-07-22 | — | — | US | disclosed |
| EP-0503548-B1 | Cyclic urea derivatives, medicaments contaning them and process for their preparation | THOMAE GMBH DR K (DE) | 1997-06-04 | — | — | EP | disclosed |
| US-5478942-A | Antiinflammatory agents, antiagglomerants | KARL THOMAE GMBH (DE) | 1995-12-26 | — | — | US | disclosed |
| US-5276049-A | Treatment of thrombosis | DR. KARL THOMAE GMBH (DE) | 1994-01-04 | — | — | US | disclosed |
| EP-0503548-A1 | Cyclic urea derivatives, medicaments contaning them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-09-16 | — | — | EP | disclosed |