⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1887286 | 0.74 | — | — | |
| SCHEMBL338859 | 0.70 | — | — | |
| SCHEMBL832955 | 0.70 | — | — | |
| SCHEMBL27835276 | 0.67 | — | — | |
| SCHEMBL9454895 | 0.67 | — | — | |
| SCHEMBL831271 | 0.67 | — | — | |
| SCHEMBL6860057 | 0.59 | — | — | |
| SCHEMBL1499780 | 0.59 | — | — | |
| SCHEMBL2169129 | 0.59 | — | — | |
| SCHEMBL22042138 | 0.59 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723442-A | OLIGOPEPTIDES AS HUMAN LEUKOCYTE ELASTASE INHIBITORS | ZENECA INC. (US) | 1998-03-03 | — | — | US | claimed |
| EP-0399688-B1 | Trifluoroketopeptide derivatives useful as human leukocyte elastase inhibitors | ZENECA INC (US) | 1994-06-22 | — | — | EP | claimed |
| EP-0397427-B1 | Fluoro-amide derivatives having human leucocyte elastase inhibiting activity | ZENECA INC (US) | 1994-05-04 | — | — | EP | claimed |
| EP-0291234-B1 | Peptidic human leukocyte elastase (HLE) inhibitors | ZENECA INC (US) | 1994-03-23 | — | — | EP | claimed |
| US-5270301-A | Fluoro-amide derivatives | ICI AMERICAS INC. (US) | 1993-12-14 | — | — | US | claimed |
| US-5164371-A | HETEROCYCLIC KETONES | ICI AMERICAS INC. (US) | 1992-11-17 | — | — | US | claimed |
| EP-0509341-A1 | Cyanothiazole derivatives | BAYER AG (DE) | 1992-10-21 | — | — | EP | claimed |
| EP-0399688-A1 | Trifluoroketopeptide derivatives useful as human leukocyte elastase inhibitors | ZENECA INC. (US) | 1990-11-28 | — | — | EP | claimed |
| EP-0397427-A1 | Fluoro-amide derivatives having human leucocyte elastase inhibiting activity | ZENECA INC. (US) | 1990-11-14 | — | — | EP | claimed |
| EP-0291234-A2 | Peptidic human leukocyte elastase (HLE) inhibitors | ZENECA INC. (US) | 1988-11-17 | — | — | EP | claimed |
| US-5723442-A | OLIGOPEPTIDES AS HUMAN LEUKOCYTE ELASTASE INHIBITORS | ZENECA INC. (US) | 1998-03-03 | — | — | US | disclosed |
| EP-0399688-B1 | Trifluoroketopeptide derivatives useful as human leukocyte elastase inhibitors | ZENECA INC (US) | 1994-06-22 | — | — | EP | disclosed |
| EP-0397427-B1 | Fluoro-amide derivatives having human leucocyte elastase inhibiting activity | ZENECA INC (US) | 1994-05-04 | — | — | EP | disclosed |
| EP-0291234-B1 | Peptidic human leukocyte elastase (HLE) inhibitors | ZENECA INC (US) | 1994-03-23 | — | — | EP | disclosed |
| US-5270301-A | Fluoro-amide derivatives | ICI AMERICAS INC. (US) | 1993-12-14 | — | — | US | disclosed |
| US-5164371-A | HETEROCYCLIC KETONES | ICI AMERICAS INC. (US) | 1992-11-17 | — | — | US | disclosed |
| EP-0509341-A1 | Cyanothiazole derivatives | BAYER AG (DE) | 1992-10-21 | — | — | EP | disclosed |
| EP-0399688-A1 | Trifluoroketopeptide derivatives useful as human leukocyte elastase inhibitors | ZENECA INC. (US) | 1990-11-28 | — | — | EP | disclosed |
| EP-0397427-A1 | Fluoro-amide derivatives having human leucocyte elastase inhibiting activity | ZENECA INC. (US) | 1990-11-14 | — | — | EP | disclosed |
| EP-0291234-A2 | Peptidic human leukocyte elastase (HLE) inhibitors | ZENECA INC. (US) | 1988-11-17 | — | — | EP | disclosed |