SCHEMBL7277287

SCHEMBL7277287

CC(C)(C)NC(=O)[C@@H]1CCCCN1C[C@@H](O)[C@@H](N)Cc1ccccc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
F2 P00734 5/20 0.49
CNR2 P34972 2/20 0.44
ADORA3 P0DMS8 1/20 0.44
ADORA2A P29274 1/20 0.44
ADORA2B P29275 1/20 0.44
ADORA1 P30542 1/20 0.44
CYP3A4 P08684 3/20 0.43
ABCC3 O15438 1/20 0.43
ABCC4 O15439 1/20 0.43
CACNA1F O60840 1/20 0.43
ABCB11 O95342 1/20 0.43
ABCB1 P08183 1/20 0.43
HTR1A P08908 1/20 0.43
DRD2 P14416 1/20 0.43
TACR2 P21452 1/20 0.43
TBXAS1 P24557 1/20 0.43
OPRM1 P35372 1/20 0.43
DRD3 P35462 1/20 0.43
AVPR1A P37288 1/20 0.43
OPRD1 P41143 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8241847 0.97 F2 (0.52) F2CNR2ADORA3ADORA2AADORA2B
Hydrochloric Acid SCHEMBL495583 0.96 F2 (0.54) F2CNR2ADORA3ADORA2AADORA2B
Hydrochloric Acid SCHEMBL495585 0.96 F2 (0.54) F2CNR2ADORA3ADORA2AADORA2B
SCHEMBL7388298 0.85 CYP3A4 (0.41) F2ADORA3ADORA2AADORA2BADORA1
SCHEMBL7277234 0.85 CYP3A4 (0.58) F2ADORA3ADORA2AADORA2BADORA1
SCHEMBL14948891 0.85 CYP3A4 (0.58) F2ADORA3ADORA2AADORA2BADORA1
SCHEMBL28744665 0.85 CYP3A4 (0.58) F2ADORA3ADORA2AADORA2BADORA1
SCHEMBL14308085 0.85 CYP3A4 (0.58) F2ADORA3ADORA2AADORA2BADORA1
SCHEMBL9092461 0.85 CYP3A4 (0.58) F2ADORA3ADORA2AADORA2BADORA1
SCHEMBL28744668 0.85 CYP3A4 (0.58) F2ADORA3ADORA2AADORA2BADORA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5652369-A PROTEASE INHIBITOR HOFFMANN-LA ROCHE INC. (US) 1997-07-29 US disclosed
US-5620987-A Amino acid derivatives HOFFMANN-LA ROCHE INC. (US) 1997-04-15 US disclosed
US-5554756-A PROTEASE INHIBITOR HOFFMANN-LA ROCHE INC. (US) 1996-09-10 US disclosed
US-5446161-A Protease inhibitor, viricides HOFFMANN-LA ROCHE INC. (US) 1995-08-29 US disclosed
EP-0346847-B1 Amino acid derivatives HOFFMANN LA ROCHE (CH) 1994-05-11 EP disclosed
US-5157041-A Viricides HOFFMANN-LA ROCHE INC. (US) 1992-10-20 US disclosed
EP-0346847-A2 Amino acid derivatives F. HOFFMANN-LA ROCHE AG (CH) 1989-12-20 EP disclosed