Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.51 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
| ▸ | EFNA1 | P20827 | 1/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | SHBG | P04278 | 1/20 | 0.41 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27803736 | 0.85 | CYP19A1 (0.55) | CYP19A1GPBAR1LMNAHSD17B10EPHA2 | |
| SCHEMBL3651590 | 0.85 | CYP19A1 (0.51) | CYP19A1GPBAR1LMNAHSD17B10EPHA2 | |
| SCHEMBL27766908 | 0.85 | CYP19A1 (0.55) | CYP19A1GPBAR1LMNAHSD17B10EPHA2 | |
| SCHEMBL9938333 | 0.85 | CYP19A1 (0.51) | CYP19A1GPBAR1LMNAHSD17B10EPHA2 | |
| SCHEMBL13988200 | 0.85 | CYP19A1 (0.55) | CYP19A1GPBAR1LMNAHSD17B10EPHA2 | |
| SCHEMBL29434780 | 0.84 | CYP19A1 (0.50) | CYP19A1GPBAR1LMNAHSD17B10EPHA2 | |
| SCHEMBL6271938 | 0.83 | CYP19A1 (0.49) | CYP19A1GPBAR1LMNAHSD17B10EPHA2 | |
| SCHEMBL28576202 | 0.83 | CYP19A1 (0.49) | CYP19A1GPBAR1LMNAHSD17B10EPHA2 | |
| SCHEMBL7287422 | 0.83 | CYP19A1 (0.49) | CYP19A1GPBAR1LMNAHSD17B10EPHA2 | |
| SCHEMBL29426371 | 0.83 | GPBAR1 (0.51) | CYP19A1GPBAR1LMNAHSD17B10EPHA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0583579-B1 | New 17-hydroxyiminomethyl-5beta, 14beta-androstane derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing same | SIGMA TAU IND FARMACEUTI (IT) | 1997-12-03 | — | — | EP | disclosed |
| EP-0583579-A2 | New 17-hydroxyiminomethyl-5beta, 14beta-androstane derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing same | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 1994-02-23 | — | — | EP | disclosed |