Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 8/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 8/20 | 1.00 |
| ▸ | MEN1 | O00255 | 8/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 8/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 7/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 7/20 | 1.00 |
| ▸ | MAPT | P10636 | 7/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 1.00 |
| ▸ | TSHR | P16473 | 6/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 6/20 | 1.00 |
| ▸ | LMNA | P02545 | 5/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 1.00 |
| ▸ | USP2 | O75604 | 4/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 2/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | PDE5A | O76074 | 7/20 | 0.79 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.79 |
| ▸ | GBA1 | P04062 | 3/20 | 0.79 |
| ▸ | TP53 | P04637 | 2/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7286130 | 0.89 | PDE5A (1.00) | CYP1A2CYP3A4MEN1KMT2ACYP2D6 | |
| SCHEMBL7277274 | 0.87 | CYP1A2 (1.00) | CYP1A2CYP3A4MEN1KMT2ACYP2D6 | |
| SCHEMBL7279378 | 0.87 | MEN1 (0.84) | CYP1A2CYP3A4MEN1KMT2ACYP2D6 | |
| SCHEMBL7281010 | 0.87 | PDE5A (1.00) | CYP1A2CYP3A4MEN1KMT2ACYP2D6 | |
| SCHEMBL12176116 | 0.85 | KMT2A (0.75) | CYP1A2CYP3A4MEN1KMT2ACYP2D6 | |
| SCHEMBL7287929 | 0.84 | PDE5A (0.74) | CYP1A2CYP3A4MEN1KMT2ACYP2D6 | |
| SCHEMBL7432190 | 0.84 | MAPT (0.74) | CYP1A2CYP3A4MEN1KMT2ACYP2D6 | |
| SCHEMBL1064854 | 0.84 | CYP1A2 (1.00) | CYP1A2CYP3A4MEN1KMT2ACYP2D6 | |
| SCHEMBL14475051 | 0.83 | MAPT (0.73) | CYP1A2CYP3A4MEN1KMT2ACYP2D6 | |
| Hydrochloric Acid SCHEMBL7289885 | 0.83 | PDE5A (0.73) | CYP1A2CYP3A4MEN1KMT2ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579496-B1 | 4-Aminoquinazoline derivatives, and their use as medicine | ONO PHARMACEUTICAL CO (JP) | 2001-11-14 | — | — | EP | claimed |
| EP-0579496-A1 | 4-Aminoquinazoline derivatives, and their use as medicine | ONO PHARMACEUTICAL CO., LTD. (JP) | 1994-01-19 | — | — | EP | claimed |
| EP-0579496-B1 | 4-Aminoquinazoline derivatives, and their use as medicine | ONO PHARMACEUTICAL CO (JP) | 2001-11-14 | — | — | EP | disclosed |
| US-5439895-A | Cardiovascular disorders; inhibitor of thromboxane A2 synthetase and cyclic guanosine 3',5'-monophosphate | ONO PHARMACEUTICAL CO., LTD. (JP) | 1995-08-08 | — | — | US | disclosed |
| US-5436233-A | Nervous system disorders | ONO PHARMACEUTICAL CO., LTD. (JP) | 1995-07-25 | — | — | US | disclosed |
| EP-0579496-A1 | 4-Aminoquinazoline derivatives, and their use as medicine | ONO PHARMACEUTICAL CO., LTD. (JP) | 1994-01-19 | — | — | EP | disclosed |