Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KHK | P50053 | 6/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7387665 | 0.92 | KHK (0.46) | KHKHRH3TP53S1PR1EPHX2 | |
| SCHEMBL7273643 | 0.87 | HRH3 (0.43) | KHKHRH3TP53S1PR1HDAC1 | |
| SCHEMBL7282065 | 0.85 | HRH3 (0.41) | KHKHRH3TP53S1PR1HDAC1 | |
| Hydrochloric Acid SCHEMBL8897736 | 0.85 | KHK (0.37) | KHKHRH3S1PR1HDAC1EPHX2 | |
| Hydrochloric Acid SCHEMBL7394184 | 0.84 | HRH3 (0.41) | KHKHRH3TP53S1PR1HDAC1 | |
| SCHEMBL7282879 | 0.83 | F10 (0.46) | HRH3S1PR1F10ITGB3ITGA2B | |
| SCHEMBL7275627 | 0.83 | KHK (0.44) | KHKHDAC1ALDH1A1SMN1; SMN2ITGB3 | |
| SCHEMBL7272988 | 0.83 | F10 (0.54) | F10 | |
| SCHEMBL22404653 | 0.82 | HRH3 (0.40) | KHKHRH3TP53EPHX2 | |
| SCHEMBL7274642 | 0.81 | S1PR1 (0.41) | KHKHRH3S1PR1HDAC1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5852192-A | Cyclic urea derivatives, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1998-12-22 | — | — | US | disclosed |
| US-5650424-A | ANTIAGGLOMERANTS USING IMIDAZOLIDINDIONES | DR. KARL THOMAE GMBH (DE) | 1997-07-22 | — | — | US | disclosed |
| EP-0503548-B1 | Cyclic urea derivatives, medicaments contaning them and process for their preparation | THOMAE GMBH DR K (DE) | 1997-06-04 | — | — | EP | disclosed |
| US-5478942-A | Antiinflammatory agents, antiagglomerants | KARL THOMAE GMBH (DE) | 1995-12-26 | — | — | US | disclosed |
| US-5276049-A | Treatment of thrombosis | DR. KARL THOMAE GMBH (DE) | 1994-01-04 | — | — | US | disclosed |
| EP-0503548-A1 | Cyclic urea derivatives, medicaments contaning them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-09-16 | — | — | EP | disclosed |