Sugi Predict

Sugi Predict / Compounds / SCHEMBL7280564

SCHEMBL7280564

SCHEMBL7280564

CC(C)C(NC(=O)Cn1c(-c2ccccc2)ccc(NC(=O)NCc2ccccc2)c1=O)(O[SiH](C)C)C(C(C)(C)C)C(F)(F)F

nearest known ligand 0.61

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ ELANE P08246 20/20 0.61
▸ CTRC Q99895 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7276483 0.90 ELANE (0.59) ELANECTRC
SCHEMBL9584313 0.85 ELANE (0.53) ELANECTRC
SCHEMBL7284142 0.85 ELANE (0.54) ELANECTRC
SCHEMBL7282490 0.84 ELANE (0.44) ELANECTRC
SCHEMBL9011660 0.84 ELANE (0.57) ELANECTRC
SCHEMBL9585469 0.84 ELANE (0.55) ELANECTRC
SCHEMBL9011905 0.84 ELANE (0.57) ELANECTRC
SCHEMBL9011657 0.83 ELANE (0.65) ELANECTRC
SCHEMBL7274877 0.83 ELANE (0.56) ELANECTRC
SCHEMBL7286150 0.83 ELANE (0.65) ELANECTRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5521179-A Heterocyclic amides ZENECA LIMITED (GB) 1996-05-28 — — US disclosed
EP-0509769-A2 Heterocyclic amides having HLE inhibiting activity ZENECA LIMITED (GB) 1992-10-21 — — EP disclosed