Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 6/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.54 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.38 |
| ▸ | CYP21A2 | P08686 | 2/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7280326 | 0.70 | PDE3B (1.00) | PDE3BPDE3AMAOBPDE4APDE4B | |
| SCHEMBL11015670 | 0.70 | PDE3B (0.66) | PDE3BPDE3AMAOBPDE4APDE4B | |
| SCHEMBL7280332 | 0.70 | PDE3B (1.00) | PDE3BPDE3AMAOBPDE4APDE4B | |
| SCHEMBL11015667 | 0.70 | PDE3B (0.66) | PDE3BPDE3AMAOBPDE4APDE4B | |
| SCHEMBL2604923 | 0.64 | CYP3A4 (0.69) | PDE3BPDE3AMAOBCYP17A1CYP21A2 | |
| SCHEMBL8392726 | 0.64 | CYP3A4 (0.69) | PDE3BPDE3AMAOBCYP17A1CYP21A2 | |
| SCHEMBL138658 | 0.63 | MAPT (0.56) | CYP11B1MAPTLMNAKDM4EMEN1 | |
| SCHEMBL13126938 | 0.62 | CYP3A4 (0.51) | PDE3BPDE3AMAOBCYP17A1CYP21A2 | |
| SCHEMBL8288350 | 0.62 | MAPT (0.60) | PDE3BPDE3AMAOBMAPTLMNA | |
| SCHEMBL209879 | 0.62 | MAPT (0.60) | PDE3BPDE3AMAOBMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0145450-A2 | 6- [2-[4-(1H-imidazol-1-yl)phenyl]-alkylene and alkylenyl]-3(2H)-pyridazinones, the 4,5-dihydro- pyridazinone derivatives thereof, and a process for the preparation thereof | WARNER-LAMBERT COMPANY (US) | 1985-06-19 | — | — | EP | disclosed |