Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 8/20 | 0.60 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.60 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.60 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.60 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.60 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.60 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.60 |
| ▸ | APP | P05067 | 1/20 | 0.60 |
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.51 |
| ▸ | CCR1 | P32246 | 4/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6312225 | 0.87 | PSEN1 (0.72) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7278743 | 0.84 | PSEN1 (0.75) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7392856 | 0.81 | KLK5 (0.67) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL22036248 | 0.80 | KLK5 (0.52) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7439457 | 0.80 | PSEN1 (0.63) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7439460 | 0.80 | PSEN1 (0.63) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7301081 | 0.79 | PSEN1 (0.74) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7789578 | 0.79 | KLK5 (0.62) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9016587 | 0.79 | KLK5 (0.62) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5371202 | 0.79 | KLK5 (0.62) | RENPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5258362-A | Enzyme inhibitors, amides with oxetane ring | ABBOTT LABORATORIES (US) | 1993-11-02 | — | — | US | disclosed |
| US-5063208-A | Cardiovascular disorders, vision defects | ABBOTT LABORATORIES (US) | 1991-11-05 | — | — | US | disclosed |
| EP-0416393-A1 | Peptidyl difluorodiol renin inhibitors | ABBOTT LABORATORIES (US) | 1991-03-13 | — | — | EP | disclosed |
| EP-0410260-A2 | Peptidyl aminodiol renin inhibitors | ABBOTT LABORATORIES (US) | 1991-01-30 | — | — | EP | disclosed |
| EP-0341602-A2 | Renin-inhibiting functionalized peptidyl aminodiols and - triols | ABBOTT LABORATORIES (US) | 1989-11-15 | — | — | EP | disclosed |
| EP-0307837-A2 | Renin-inhibiting peptidyl heterocycles | ABBOTT LABORATORIES (US) | 1989-03-22 | — | — | EP | disclosed |