Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 8/20 | 0.45 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.40 |
| ▸ | GUSB | P08236 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | PLAT | P00750 | 1/20 | 0.38 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | METAP1 | P53582 | 1/20 | 0.37 |
| ▸ | CBFB | Q13951 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7270866 | 0.90 | PDE5A (0.55) | PDE5AJMJD6PDE3BPDE3ANPC1 | |
| SCHEMBL7279872 | 0.88 | CBFB (0.46) | PDE5APDE3BPDE3ANPC1RAB9A | |
| SCHEMBL7277991 | 0.88 | PDE5A (0.59) | PDE5AJMJD6PDE3BPDE3ANPC1 | |
| SCHEMBL9635782 | 0.87 | PDE5A (0.44) | PDE5APDE3BPDE3APDE10AGUSB | |
| SCHEMBL7270925 | 0.86 | PDE5A (0.56) | PDE5AJMJD6PDE3BPDE3ANPC1 | |
| SCHEMBL7272286 | 0.86 | PDE2A (0.50) | PDE5APDE3BPDE3ANPC1RAB9A | |
| SCHEMBL7278432 | 0.85 | PDE5A (0.43) | PDE5APDE3BPDE3ANPC1PDE10A | |
| SCHEMBL7272133 | 0.84 | PDE5A (0.42) | PDE5APDE3BPDE3ANPC1RAB9A | |
| SCHEMBL9635639 | 0.84 | PDE5A (0.62) | PDE5APDE10AGUSBKDM4EALDH1A1 | |
| SCHEMBL7278114 | 0.83 | PDE5A (0.42) | PDE5AJMJD6PDE3BPDE3ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4904785-A | INOTROPIC AGENTS FOR CARDIOVASCULAR DISORDERS | ELI LILLY AND COMPANY (US) | 1990-02-27 | — | — | US | disclosed |
| US-4758574-A | 2-phenylimidazio (4,5-c) pyridines | ELI LILLY AND COMPANY (US) | 1988-07-19 | — | — | US | disclosed |
| EP-0093593-A2 | Pyridine compounds | ELI LILLY AND COMPANY (US) | 1983-11-09 | — | — | EP | disclosed |