Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 6/20 | 0.57 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.40 |
| ▸ | SRC | P12931 | 6/20 | 0.34 |
| ▸ | PTK6 | Q13882 | 6/20 | 0.34 |
| ▸ | HCK | P08631 | 3/20 | 0.34 |
| ▸ | FYN | P06241 | 2/20 | 0.34 |
| ▸ | BLK | P51451 | 2/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | LYN | P07948 | 1/20 | 0.34 |
| ▸ | FRK | P42685 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 9/20 | 0.33 |
| ▸ | KDR | P35968 | 4/20 | 0.33 |
| ▸ | EGFR | P00533 | 4/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.33 |
| ▸ | PRKDC | P78527 | 3/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL726560 | 0.84 | RET (0.69) | RETRIPK2SRCPTK6FYN | |
| SCHEMBL728046 | 0.81 | RET (0.69) | RETRIPK2SRCPTK6FYN | |
| SCHEMBL727071 | 0.81 | RET (0.53) | RETRIPK2KDREGFRBTK | |
| SCHEMBL727933 | 0.80 | RET (0.62) | RETRIPK2SRCABL1KDR | |
| SCHEMBL726637 | 0.80 | RET (0.76) | RETRIPK2SRCPTK6HCK | |
| SCHEMBL728198 | 0.79 | RIPK2 (0.64) | RETRIPK2SRCPTK6HCK | |
| SCHEMBL19265932 | 0.79 | RIPK2 (0.64) | RETRIPK2SRCPTK6HCK | |
| SCHEMBL10098363 | 0.79 | RET (0.61) | RETRIPK2SRCABL1KDR | |
| SCHEMBL726543 | 0.78 | RET (0.80) | RETRIPK2SRCPTK6HCK | |
| SCHEMBL726555 | 0.78 | RET (0.60) | RETRIPK2SRCABL1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012003544-A1 | PROTEIN KINASE INHIBITORS AND METHODS OF TREATMENT | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2012-01-12 | — | — | WO | disclosed |