Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 7/20 | 0.46 |
| ▸ | ADH1B | P00325 | 2/20 | 0.40 |
| ▸ | ADH1C | P00326 | 2/20 | 0.40 |
| ▸ | ADH1A | P07327 | 2/20 | 0.40 |
| ▸ | ADH7 | P40394 | 2/20 | 0.40 |
| ▸ | ADH4 | P08319 | 1/20 | 0.40 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29658268 | 0.97 | EPHX1 (0.50) | TSHRALDH1A1EPHX1ADH1BADH1C | |
| SCHEMBL30368694 | 0.91 | TSHR (0.43) | TSHRALDH1A1EPHX1ADH1BADH1C | |
| SCHEMBL578890 | 0.82 | — | — | |
| SCHEMBL258474 | 0.80 | EPHX1 (0.50) | TSHRALDH1A1EPHX1ADH1BADH1C | |
| SCHEMBL578496 | 0.80 | EPHX1 (0.50) | TSHRALDH1A1EPHX1ADH1BADH1C | |
| SCHEMBL258725 | 0.80 | EPHX1 (0.50) | TSHRALDH1A1EPHX1ADH1BADH1C | |
| SCHEMBL11862257 | 0.80 | EPHX1 (0.50) | TSHRALDH1A1EPHX1ADH1BADH1C | |
| SCHEMBL1903292 | 0.80 | EPHX1 (0.50) | TSHRALDH1A1EPHX1ADH1BADH1C | |
| SCHEMBL258373 | 0.80 | EPHX1 (0.50) | TSHRALDH1A1EPHX1ADH1BADH1C | |
| SCHEMBL464960 | 0.80 | EPHX1 (0.50) | TSHRALDH1A1EPHX1ADH1BADH1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0422937-B1 | Fibrinogen receptor antagonists | MERCK & CO INC (US) | 1994-03-02 | — | — | EP | claimed |
| EP-0422938-B1 | Fibrinogen receptor antagonists | MERCK & CO INC (US) | 1995-02-22 | — | — | EP | disclosed |
| US-5374622-A | Modified cyclic heptapeptides | MERCK & CO., INC. (US) | 1994-12-20 | — | — | US | disclosed |
| US-5338723-A | Anticoagulants and thrombus preventatives comprising cyclic hexapeptides having a synthetic amino acid replace arginine in the sequence of arginine/glycine/aspartic acid | MERCK & CO., INC. (US) | 1994-08-16 | — | — | US | disclosed |
| EP-0422937-B1 | Fibrinogen receptor antagonists | MERCK & CO INC (US) | 1994-03-02 | — | — | EP | disclosed |
| EP-0422938-A1 | Fibrinogen receptor antagonists | MERCK & CO. INC. (US) | 1991-04-17 | — | — | EP | disclosed |
| EP-0422937-A1 | Fibrinogen receptor antagonists | MERCK & CO. INC. (US) | 1991-04-17 | — | — | EP | disclosed |