Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 6/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.50 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.50 |
| ▸ | AXL | P30530 | 2/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9468077 | 0.86 | MAP4K4 (0.43) | METMAPK10PIK3CDPIK3CAMTOR | |
| SCHEMBL9060837 | 0.86 | MAPK10 (0.45) | METMAPK10MAP4K4NPC1RAB9A | |
| SCHEMBL8867498 | 0.84 | MAPK10 (0.50) | METMAPK10PSMB5AXLPIK3CD | |
| SCHEMBL9148740 | 0.83 | MAPK10 (0.49) | METMAPK10PSMB5AXLPIK3CD | |
| SCHEMBL8681101 | 0.79 | PIK3CA (0.56) | MAPK10PIK3CAMAP4K4PTPN1PTPN2 | |
| SCHEMBL8867238 | 0.78 | ERN1 (0.40) | ERN1SMN1; SMN2PDGFRA | |
| SCHEMBL27442849 | 0.78 | ERN1 (0.47) | METMAPK10ERN1NPC1RAB9A | |
| SCHEMBL8867491 | 0.77 | HTT (0.41) | ERN1NPC1RAB9A | |
| SCHEMBL8867707 | 0.77 | KMT2A (0.46) | ERN1NPC1RAB9A | |
| SCHEMBL27538705 | 0.77 | ERN1 (0.33) | METMAPK10AXLPIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5650514-A | 3-substituted quinoline-5-carboxylic acid derivatives and processes for their preparation | BAYER AKTIENGESELLSCHAFT (DE) | 1997-07-22 | — | — | US | disclosed |
| EP-0622366-B1 | Condensed quinolyl-dihydropyridines, process for their preparation and their use in medicine for the treatment of heart-circulatory illnesses | BAYER AG (DE) | 1996-12-04 | — | — | EP | disclosed |
| EP-0515940-B1 | New 2-amino-5-cyano-1,4-dihydropyridines, process for their preparation and use in pharmaceutical compositions | BAYER AG (DE) | 1996-07-17 | — | — | EP | disclosed |
| US-5514803-A | CARDIOVASCULAR CIRCULATORY DISORDERS | BAYER AKTIENGESELLSCHAFT (DE) | 1996-05-07 | — | — | US | disclosed |
| US-5508406-A | FOR TREATING CARDIOVASCULAR DISORDERS | BAYER AKTIENGESELLSCHAFT (DE) | 1996-04-16 | — | — | US | disclosed |
| US-5502062-A | CARDIOVASCULAR DISORDERS, MYOCARDIAL CONTRACTILITY | BAYER AKTIENGESELLSCHAFT (DE) | 1996-03-26 | — | — | US | disclosed |
| CN-1116622-A | 3-substituted quinoline-5-carboxylic acid derivatives and process for producing the same | BAYER AG (DE) | 1996-02-14 | — | — | CN | disclosed |
| EP-0694534-A1 | 3-Substituted quinoline-5-carboxylic acid derivatives and processes for their preparation | BAYER AG (DE) | 1996-01-31 | — | — | EP | disclosed |
| US-5436342-A | Cardiovascular disorders and muscular disorders | BAYER AKTIENGELSELLSCHAFT (DE) | 1995-07-25 | — | — | US | disclosed |
| US-5432282-A | Cardiovascular disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1995-07-11 | — | — | US | disclosed |
| EP-0622369-A2 | 2-Amino-4-quinoline-dihydropyridine, process for preparation and use thereof | BAYER AG (DE) | 1994-11-02 | — | — | EP | disclosed |
| EP-0622364-A2 | 2,6-Disubstituted-4-quinolyl-dihydropyridines | BAYER AG (DE) | 1994-11-02 | — | — | EP | disclosed |
| EP-0538690-B1 | Arylquinoline substituted 1,4-dihydropyridine dicarboxylic derivatives, process for their preparation and their use as drugs | BAYER AG (DE) | 1994-09-28 | — | — | EP | disclosed |
| US-5262429-A | CARDIOTONIC AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1993-11-16 | — | — | US | disclosed |
| US-5225558-A | Cardiovascular disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1993-07-06 | — | — | US | disclosed |
| EP-0538690-A1 | Arylquinoline substituted 1,4-dihydropyridine dicarboxylic derivatives, process for their preparation and their use as drugs | BAYER AG (DE) | 1993-04-28 | — | — | EP | disclosed |
| US-5204472-A | For preparing inotropic agents; substituted dihydropyridines | BAYER AKTIENGESELLSCHAFT (DE) | 1993-04-20 | — | — | US | disclosed |
| EP-0515940-A1 | New 2-amino-5-cyano-1,4-dihydropyridines, process for their preparation and use in pharmaceutical compositions | BAYER AG (DE) | 1992-12-02 | — | — | EP | disclosed |
| US-5100900-A | Inotropic agents | BAYER AKTIENGESELLSCHAFT (DE) | 1992-03-31 | — | — | US | disclosed |
| EP-0452712-A1 | 4-Quinolyl-dihydropyridines, process for their prepatation and their use in medicaments | BAYER AG (DE) | 1991-10-23 | — | — | EP | disclosed |