Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.60 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.60 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.60 |
| ▸ | PGR | P06401 | 1/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8881974 | 0.93 | PDE3B (0.58) | PDE3BPDE3ANR3C1PGRSLC6A4 | |
| SCHEMBL7283613 | 0.92 | PDE3B (0.61) | PDE3BPDE3ANR3C1PGRSLC6A4 | |
| SCHEMBL7285284 | 0.92 | PDE3B (0.61) | PDE3BPDE3ANR3C1PGRSLC6A4 | |
| SCHEMBL7283459 | 0.92 | PDE3B (0.61) | PDE3BPDE3ANR3C1PGRSLC6A4 | |
| SCHEMBL8880351 | 0.89 | PDE3B (0.58) | PDE3BPDE3ANR3C1PGRSLC6A4 | |
| SCHEMBL7290681 | 0.89 | PDE3B (0.60) | PDE3BPDE3ANR3C1PGRSLC6A4 | |
| SCHEMBL7292245 | 0.89 | PDE3B (0.64) | PDE3BPDE3ANR3C1PGRSLC6A4 | |
| SCHEMBL10655348 | 0.88 | PDE3B (0.59) | PDE3BPDE3ANR3C1PGRSLC6A4 | |
| SCHEMBL7291575 | 0.88 | PDE3B (0.56) | PDE3BPDE3ANR3C1PGRSLC6A4 | |
| SCHEMBL7282655 | 0.88 | PDE3B (0.58) | PDE3BPDE3ANR3C1PGRSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4760064-A | Cardiotonic agent | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-07-26 | — | — | US | claimed |
| EP-0187322-A1 | Carbostyril compounds, compositions containing same and processes for preparing same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-07-16 | — | — | EP | claimed |
| US-4760064-A | Cardiotonic agent | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-07-26 | — | — | US | disclosed |
| EP-0187322-A1 | Carbostyril compounds, compositions containing same and processes for preparing same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-07-16 | — | — | EP | disclosed |