Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7284746 | 0.94 | KDM4E (0.40) | TP53THRBKDM4EALDH1A1HPGD | |
| SCHEMBL7284947 | 0.89 | GLA (0.42) | KDM4EALDH1A1HPGDTDP1LMNA | |
| SCHEMBL7292620 | 0.85 | KDM4E (0.50) | KDM4EALDH1A1HPGDTDP1LMNA | |
| SCHEMBL7292117 | 0.85 | ROCK1 (0.43) | TP53KDM4EALDH1A1HPGDLMNA | |
| SCHEMBL4590994 | 0.84 | HSD17B10 (0.48) | TP53KDM4EALDH1A1HPGDLMNA | |
| SCHEMBL7292041 | 0.83 | KDM4E (0.51) | KDM4EALDH1A1HPGDTDP1LMNA | |
| SCHEMBL7292378 | 0.83 | GLA (0.41) | TP53KDM4EALDH1A1HPGDTDP1 | |
| SCHEMBL4590902 | 0.82 | CFTR (0.40) | KDM4EALDH1A1HPGDCYP1A2CYP3A4 | |
| SCHEMBL7282998 | 0.82 | LATS1 (0.49) | TP53KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL7291097 | 0.81 | SMN1; SMN2 (0.48) | TP53THRBKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0200024-B1 | 3-CYANO-PYRIDINES, PROCESS FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE | ARZNEIMITTELWERK DRESDEN GmbH (DE) | 1992-07-01 | — | — | EP | disclosed |
| EP-0200024-A2 | 3-Cyano-pyridines, process for their preparation and their pharmaceutical use | ARZNEIMITTELWERK DRESDEN GmbH (DE) | 1986-11-05 | — | — | EP | disclosed |