SCHEMBL7284339

SCHEMBL7284339

CCC(NC(=O)Cn1c(-c2ccccc2)ccc(NC(=O)OCc2ccccc2)c1=O)C(=O)C(F)(F)F

nearest known ligand 0.80

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ELANE P08246 20/20 0.80
CTRC Q99895 3/20 0.80

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6557645 0.92 ELANE (0.78) ELANECTRC
SCHEMBL7282527 0.89 ELANE (1.00) ELANECTRC
SCHEMBL6556311 0.88 ELANE (0.79) ELANECTRC
SCHEMBL6556339 0.87 ELANE (0.71) ELANECTRC
SCHEMBL7276446 0.86 ELANE (0.70) ELANECTRC
SCHEMBL6556064 0.86 ELANE (0.81) ELANECTRC
SCHEMBL6558200 0.85 ELANE (0.73) ELANECTRC
SCHEMBL7276598 0.85 ELANE (1.00) ELANECTRC
SCHEMBL7447790 0.84 ELANE (0.69) ELANECTRC
SCHEMBL7282775 0.84 ELANE (1.00) ELANECTRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5521179-A Heterocyclic amides ZENECA LIMITED (GB) 1996-05-28 US disclosed
EP-0509769-A2 Heterocyclic amides having HLE inhibiting activity ZENECA LIMITED (GB) 1992-10-21 EP disclosed