Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | CPT2 | P23786 | 1/20 | 0.51 |
| ▸ | CPT1A | P50416 | 1/20 | 0.51 |
| ▸ | ACE | P12821 | 10/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.45 |
| ▸ | TACR1 | P25103 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL7283171 | 0.99 | NPC1 (0.51) | NPC1RAB9ACPT2CPT1AACE | |
| SCHEMBL7283694 | 0.90 | NPC1 (0.53) | NPC1RAB9ACPT2CPT1AACE | |
| SCHEMBL7283502 | 0.89 | CPT2 (0.49) | NPC1RAB9ACPT2CPT1AACE | |
| SCHEMBL9485197 | 0.89 | ACE (0.57) | NPC1RAB9ACPT2CPT1AACE | |
| SCHEMBL7282427 | 0.88 | NPC1 (0.56) | NPC1RAB9ACPT2CPT1AACE | |
| Water SCHEMBL7282829 | 0.87 | NPC1 (0.55) | NPC1RAB9ACPT2CPT1AACE | |
| SCHEMBL7294666 | 0.86 | NPC1 (0.53) | NPC1RAB9ACPT2CPT1AACE | |
| SCHEMBL7291237 | 0.86 | NPC1 (0.53) | NPC1RAB9ACPT2CPT1AACE | |
| SCHEMBL7283896 | 0.84 | NPC1 (0.53) | NPC1RAB9ACPT2CPT1AACE | |
| SCHEMBL7283022 | 0.83 | NPC1 (0.48) | NPC1RAB9ACPT2CPT1AACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5545657-A | 1-ALKYLOYLPYRROLIDIN-2-YLOXOALKANOIC ACIDS AND DERIVATIVES; ANTIAMNESIA AGENTS; INHIBITORS OF PROLYL ENDOPEPTIDASE; SUPPRESSION OF NEUROTRANSMITTER METABOLISM | ONO PHARMACEUTICAL CO., LTD. (JP) | 1996-08-13 | — | — | US | claimed |
| EP-0345428-B1 | Anti-amnesic pyrrolidine derivatives | ONO PHARMACEUTICAL CO (JP) | 1995-01-18 | — | — | EP | claimed |
| EP-0345428-A1 | Anti-amnesic pyrrolidine derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1989-12-13 | — | — | EP | claimed |