Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.49 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.49 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.49 |
| ▸ | METAP2 | P50579 | 1/20 | 0.48 |
| ▸ | METAP1 | P53582 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CTSG | P08311 | 1/20 | 0.47 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.47 |
| ▸ | ANPEP | P15144 | 2/20 | 0.46 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.46 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | MMP12 | P39900 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8170979 | 1.00 | DPP4 (0.49) | DPP4S1PR2S1PR1METAP2METAP1 | |
| SCHEMBL8170975 | 1.00 | DPP4 (0.49) | DPP4S1PR2S1PR1METAP2METAP1 | |
| Hydrochloric Acid SCHEMBL7284681 | 0.98 | DPP4 (0.48) | DPP4S1PR2S1PR1METAP2METAP1 | |
| Hydrochloric Acid SCHEMBL7274932 | 0.98 | DPP4 (0.48) | DPP4S1PR2S1PR1METAP2METAP1 | |
| Acetic Acid SCHEMBL7371940 | 0.97 | DPP4 (0.47) | DPP4S1PR2S1PR1METAP2METAP1 | |
| Acetic Acid SCHEMBL7374879 | 0.97 | DPP4 (0.47) | DPP4S1PR2S1PR1METAP2METAP1 | |
| Acetic Acid SCHEMBL7371937 | 0.97 | DPP4 (0.47) | DPP4S1PR2S1PR1METAP2METAP1 | |
| SCHEMBL2311407 | 0.84 | F2 (0.55) | DPP4S1PR2S1PR1TSHRMEN1 | |
| SCHEMBL8903673 | 0.84 | F2 (0.55) | DPP4S1PR2S1PR1TSHRMEN1 | |
| SCHEMBL6343323 | 0.83 | EPHX1 (0.53) | DPP4ANPEPSLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6114328-A | ANTICOAGULANTS; BLOOD DISORDERS | DUPONT PHARMACEUTICALS COMPANY (US) | 2000-09-05 | — | — | US | disclosed |
| EP-0512831-B1 | Fibrinogen receptor antagonists | MERCK & CO INC (US) | 1999-09-22 | — | — | EP | disclosed |
| US-5849736-A | Isoxazoline and isoxazole fibrinogen receptor antagonists | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-12-15 | — | — | US | disclosed |
| US-5455243-A | Anticoagulants | MERCK & CO., INC. (US) | 1995-10-03 | — | — | US | disclosed |
| US-5281585-A | Secondary amide containing antagonist | MERCK & CO., INC. (US) | 1994-01-25 | — | — | US | disclosed |
| WO-1992019595-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1992-11-12 | — | — | WO | disclosed |
| EP-0512831-A1 | Fibrinogen receptor antagonists | MERCK & CO. INC. (US) | 1992-11-11 | — | — | EP | disclosed |
| US-4585887-A | Process for the production of optically active 3-aminocarboxylic acid esters | LONZA LTD. (CH) | 1986-04-29 | — | — | US | disclosed |