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SCHEMBL7285642

SCHEMBL7285642

CC(C)C(NC(=O)Cn1c(-c2ccccc2)ccc(NC(=O)C(F)(F)F)c1=O)C(=O)C(F)(F)F

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ ELANE P08246 20/20 1.00
▸ CTRC Q99895 1/20 0.77

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7273489 0.94 ELANE (1.00) ELANECTRC
SCHEMBL7283164 0.91 ELANE (0.87) ELANECTRC
SCHEMBL7274343 0.91 ELANE (1.00) ELANECTRC
SCHEMBL7276649 0.91 ELANE (0.88) ELANECTRC
SCHEMBL7444071 0.91 ELANE (0.83) ELANECTRC
SCHEMBL9011925 0.91 ELANE (0.94) ELANECTRC
SCHEMBL7284369 0.91 ELANE (1.00) ELANECTRC
SCHEMBL7447281 0.89 ELANE (1.00) ELANECTRC
SCHEMBL7274521 0.89 ELANE (0.80) ELANE
SCHEMBL7437405 0.88 ELANE (0.84) ELANECTRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5521179-A Heterocyclic amides ZENECA LIMITED (GB) 1996-05-28 — — US disclosed
EP-0630382-A1 LACTAM DIPEPTIDES HAVING HLE INHIBITING ACTIVITY. ZENECA LTD (GB) 1994-12-28 — — EP disclosed
WO-1993021212-A1 LACTAM DIPEPTIDES HAVING HLE INHIBITING ACTIVITY ZENECA LIMITED (GB) 1993-10-28 — — WO disclosed
EP-0509769-A2 Heterocyclic amides having HLE inhibiting activity ZENECA LIMITED (GB) 1992-10-21 — — EP disclosed