Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 18/20 | 0.44 |
| ▸ | TMPRSS15 | P98073 | 18/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | F12 | P00748 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7285676 | 1.00 | PRSS1 (0.44) | PRSS1TMPRSS15KMT2AF12 | |
| Hydrochloric Acid SCHEMBL7276368 | 0.98 | PRSS1 (0.44) | PRSS1TMPRSS15KMT2AF12 | |
| Hydrochloric Acid SCHEMBL7276374 | 0.98 | PRSS1 (0.44) | PRSS1TMPRSS15KMT2AF12 | |
| Hydrochloric Acid SCHEMBL7279836 | 0.87 | PRSS1 (0.48) | PRSS1TMPRSS15KMT2A | |
| Hydrochloric Acid SCHEMBL7279841 | 0.87 | PRSS1 (0.48) | PRSS1TMPRSS15KMT2A | |
| Hydrochloric Acid SCHEMBL7278908 | 0.81 | PRSS1 (0.53) | PRSS1TMPRSS15KMT2A | |
| Bromide SCHEMBL7286080 | 0.81 | PRSS1 (0.47) | PRSS1TMPRSS15F12 | |
| Hydrochloric Acid SCHEMBL7285064 | 0.80 | PRSS1 (0.48) | PRSS1TMPRSS15F12 | |
| Hydrochloric Acid SCHEMBL7285071 | 0.80 | PRSS1 (0.48) | PRSS1TMPRSS15F12 | |
| SCHEMBL7305345 | 0.80 | PRSS1 (0.47) | PRSS1TMPRSS15F12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5532267-A | Amidinonaphthyl furancarboxylate derivatives and acid addition salts therof | TORII & CO., LTD. (JP) | 1996-07-02 | — | — | US | claimed |
| US-5532267-A | Amidinonaphthyl furancarboxylate derivatives and acid addition salts therof | TORII & CO., LTD. (JP) | 1996-07-02 | — | — | US | disclosed |
| EP-0556024-B1 | Novel amidinonaphthyl furancarboxylate derivatives and acid addition salts thereof | TORII & CO LTD (JP) | 1995-08-02 | — | — | EP | disclosed |
| EP-0556024-A1 | Novel amidinonaphthyl furancarboxylate derivatives and acid addition salts thereof | TORII & CO., LTD. (JP) | 1993-08-18 | — | — | EP | disclosed |