Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | ESR1 | P03372 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.56 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7285681 | 1.00 | TDP1 (0.56) | TDP1HPGDKDM4EUSP2ESR1 | |
| SCHEMBL7285087 | 0.96 | TDP1 (0.51) | TDP1HPGDKDM4EUSP2ESR1 | |
| SCHEMBL7285101 | 0.96 | TDP1 (0.51) | TDP1HPGDKDM4EUSP2ESR1 | |
| SCHEMBL7285601 | 0.91 | TDP1 (0.47) | TDP1HPGDKDM4EUSP2ESR1 | |
| SCHEMBL7285609 | 0.91 | TDP1 (0.47) | TDP1HPGDKDM4EUSP2ESR1 | |
| SCHEMBL7294847 | 0.90 | POLB (0.46) | TDP1HPGDKDM4EUSP2ESR1 | |
| SCHEMBL7294856 | 0.90 | POLB (0.46) | TDP1HPGDKDM4EUSP2ESR1 | |
| SCHEMBL7287025 | 0.90 | KDM4E (0.46) | TDP1HPGDKDM4EUSP2ESR1 | |
| SCHEMBL7287036 | 0.90 | KDM4E (0.46) | TDP1HPGDKDM4EUSP2ESR1 | |
| SCHEMBL7324499 | 0.90 | TDP1 (0.54) | TDP1HPGDKDM4EUSP2ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0353032-B1 | 1,5-BENZOTHIAZEPINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CARDIOVASCULAR DISORDERS | Sankyo Company Limited (JP) | 1992-02-26 | — | — | EP | disclosed |
| EP-0353032-A1 | 1,5-benzothiazepine derivatives, their preparation and their use in the treatment of cardiovascular disorders | Sankyo Company Limited (JP) | 1990-01-31 | — | — | EP | disclosed |