Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.70 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.70 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.70 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.70 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.70 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.70 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.70 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.70 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.70 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.70 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.70 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.61 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.61 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.59 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.59 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 6/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7287723 | 0.93 | NPC1 (0.67) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL18614948 | 0.89 | HDAC3 (0.70) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL18614936 | 0.88 | SPHK2 (0.69) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL6716502 | 0.86 | MEN1 (0.79) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL7296744 | 0.86 | SPHK2 (0.80) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL10289219 | 0.84 | HDAC3 (0.78) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL748869 | 0.84 | SPHK2 (0.81) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL7734896 | 0.84 | HDAC6 (0.91) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL13380778 | 0.83 | HPGD (0.65) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL25870996 | 0.82 | NR4A1 (0.66) | HDAC3HDAC1HDAC2HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0824098-B1 | 4-hydroxy-piperidine derivatives | HOFFMANN LA ROCHE (CH) | 2001-10-31 | — | — | EP | disclosed |
| US-5889026-A | 4-hydroxy-piperodine derivatives | HOFFMANN-LA ROCHE INC. (US) | 1999-03-30 | — | — | US | disclosed |
| EP-0824098-A1 | 4-hydroxy-piperidine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1998-02-18 | — | — | EP | disclosed |