Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 5/20 | 0.42 |
| ▸ | KCNJ5 | P48544 | 4/20 | 0.41 |
| ▸ | KCNJ3 | P48549 | 4/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | TTK | P33981 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7284967 | 0.86 | AAK1 (0.47) | AAK1ROCK2CYP3A4NR2C2CLK1 | |
| SCHEMBL9695406 | 0.84 | KCNJ5 (0.39) | AAK1KCNJ5KCNJ3ROCK2CYP3A4 | |
| SCHEMBL7291149 | 0.83 | AAK1 (0.43) | AAK1ROCK2CYP3A4NR2C2CLK1 | |
| SCHEMBL7284759 | 0.81 | AAK1 (0.42) | AAK1ROCK2CYP3A4NR2C2CLK1 | |
| SCHEMBL7286715 | 0.80 | KCNA5 (0.41) | KCNJ5KCNJ3KCNA5KCNH2ALDH1A1 | |
| SCHEMBL7439891 | 0.78 | KCNJ5 (0.41) | AAK1KCNJ5KCNJ3ROCK2CYP3A4 | |
| SCHEMBL7306378 | 0.76 | AAK1 (0.45) | AAK1ROCK2CYP3A4NR2C2CLK1 | |
| SCHEMBL7271245 | 0.76 | AURKA (0.60) | AAK1CYP3A4AURKATTKAURKB | |
| SCHEMBL7294242 | 0.75 | AURKA (0.47) | AAK1ROCK2CYP3A4NR2C2CLK1 | |
| SCHEMBL7283960 | 0.75 | ACACB (0.41) | AAK1ROCK2CYP3A4NR2C2CLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0200024-B1 | 3-CYANO-PYRIDINES, PROCESS FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE | ARZNEIMITTELWERK DRESDEN GmbH (DE) | 1992-07-01 | — | — | EP | disclosed |
| EP-0200024-A2 | 3-Cyano-pyridines, process for their preparation and their pharmaceutical use | ARZNEIMITTELWERK DRESDEN GmbH (DE) | 1986-11-05 | — | — | EP | disclosed |