Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 9/20 | 0.64 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.64 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.64 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.64 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.64 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.64 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.56 |
| ▸ | RAD52 | P43351 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | UBE2N | P61088 | 1/20 | 0.55 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | APP | P05067 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7287599 | 0.78 | PDE5A (0.65) | PDE5APTGS1TBXAS1PTGS2PDE3B | |
| SCHEMBL7280806 | 0.78 | PDE5A (1.00) | PDE5APTGS1TBXAS1PTGS2PDE3B | |
| SCHEMBL7607292 | 0.78 | LATS1 (0.44) | PDE5APTGS1TBXAS1PTGS2PDE3B | |
| SCHEMBL7610886 | 0.78 | PDE5A (0.43) | PDE5APTGS1TBXAS1PTGS2PDE3B | |
| Hydrochloric Acid SCHEMBL7279655 | 0.77 | PDE5A (0.97) | PDE5APTGS1TBXAS1PTGS2PDE3B | |
| SCHEMBL3644425 | 0.77 | PDE5A (0.67) | PDE5APTGS1TBXAS1PTGS2PDE3B | |
| SCHEMBL7607878 | 0.76 | PDE5A (0.42) | PDE5APTGS1TBXAS1PTGS2PDE3B | |
| SCHEMBL7610232 | 0.76 | PDE5A (0.42) | PDE5APTGS1TBXAS1PTGS2PDE3B | |
| SCHEMBL7280595 | 0.75 | PDE5A (0.61) | PDE5APTGS1TBXAS1PTGS2PDE3B | |
| SCHEMBL3643346 | 0.75 | PDE5A (0.79) | PDE5APTGS1TBXAS1PTGS2PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579496-B1 | 4-Aminoquinazoline derivatives, and their use as medicine | ONO PHARMACEUTICAL CO (JP) | 2001-11-14 | — | — | EP | claimed |
| EP-0579496-A1 | 4-Aminoquinazoline derivatives, and their use as medicine | ONO PHARMACEUTICAL CO., LTD. (JP) | 1994-01-19 | — | — | EP | claimed |
| EP-0579496-B1 | 4-Aminoquinazoline derivatives, and their use as medicine | ONO PHARMACEUTICAL CO (JP) | 2001-11-14 | — | — | EP | disclosed |
| EP-0579496-A1 | 4-Aminoquinazoline derivatives, and their use as medicine | ONO PHARMACEUTICAL CO., LTD. (JP) | 1994-01-19 | — | — | EP | disclosed |