Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLCN2 | P51788 | 2/20 | 0.60 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.60 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.60 |
| ▸ | MRGPRX4 | Q96LA9 | 7/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | RXRA | P19793 | 1/20 | 0.54 |
| ▸ | RXRB | P28702 | 1/20 | 0.54 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MITF | O75030 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | XBP1 | P17861 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10729722 | 0.88 | CLCN2 (0.54) | CLCN2CHRM4CHRM3MRGPRX4HPGD | |
| SCHEMBL7281267 | 0.85 | CLCN2 (0.55) | CLCN2CHRM4CHRM3MRGPRX4HPGD | |
| SCHEMBL1495326 | 0.85 | MRGPRX4 (0.54) | CLCN2CHRM4CHRM3MRGPRX4HPGD | |
| SCHEMBL7967408 | 0.79 | CLCN2 (0.53) | CLCN2CHRM4CHRM3MRGPRX4HPGD | |
| SCHEMBL14829902 | 0.77 | MRGPRX4 (0.48) | CLCN2CHRM4CHRM3MRGPRX4HPGD | |
| SCHEMBL8204822 | 0.76 | FOLH1 (0.69) | MRGPRX4HPGDRXRARXRBPTGER1 | |
| SCHEMBL27977297 | 0.76 | CLCN2 (0.61) | CLCN2CHRM4CHRM3MRGPRX4HPGD | |
| SCHEMBL7311890 | 0.76 | CLCN2 (0.51) | CLCN2CHRM4CHRM3MRGPRX4HPGD | |
| SCHEMBL1843931 | 0.76 | MEN1 (0.56) | MRGPRX4HPGDRXRARXRBPTGER1 | |
| SCHEMBL31177876 | 0.76 | MCL1 (0.61) | CLCN2CHRM4CHRM3MRGPRX4HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5597841-A | 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof | STERLING WINTHROP, INC. (US) | 1997-01-28 | — | — | US | disclosed |
| EP-0594257-B1 | 2-Saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof | STERLING WINTHROP INC (US) | 1996-07-10 | — | — | EP | disclosed |
| US-5512589-A | TREATING DEGENERATIVE DISEASES | STERLING WINTHROP INC. (US) | 1996-04-30 | — | — | US | disclosed |
| EP-0594257-A1 | 2-Saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof | STERLING WINTHROP INC. (US) | 1994-04-27 | — | — | EP | disclosed |
| US-5306818-A | Treating degenerative diseases such as emphysema, rheumatoid arthritis and pancreatitis | STERLING WINTHROP INC. (US) | 1994-04-26 | — | — | US | disclosed |
| US-5250696-A | Treatment of degenerative diseases | STERLING WINTHROP INC. (US) | 1993-10-05 | — | — | US | disclosed |
| US-5128339-A | Emphysema, rheumatoid arthritis, pancreatitis | STERLING WINTHROP INC. (US) | 1992-07-07 | — | — | US | disclosed |
| EP-0483928-A1 | 2-Saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use | STERLING WINTHROP INC. (US) | 1992-05-06 | — | — | EP | disclosed |
| US-4704401-A | HYPOTENSIVE AGENTS | RORER PHARMACEUTICAL CORPORATION (US) | 1987-11-03 | — | — | US | disclosed |
| US-4487779-A | HYPOTENSIVE AGENTS | WILLIAM H. RORER, INC. (US) | 1984-12-11 | — | — | US | disclosed |