Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | ACACB | O00763 | 1/20 | 0.30 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.30 |
| ▸ | SCD | O00767 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7300272 | 0.83 | NPC1 (0.33) | NPC1 | |
| SCHEMBL7292898 | 0.82 | NPC1 (0.34) | NPC1 | |
| SCHEMBL7378253 | 0.81 | NPC1 (0.33) | NPC1 | |
| SCHEMBL7294267 | 0.81 | NPC1 (0.32) | NPC1 | |
| SCHEMBL7297557 | 0.80 | NPC1 (0.34) | NPC1KDM4EALDH1A1 | |
| SCHEMBL7369558 | 0.79 | NPC1 (0.34) | NPC1 | |
| SCHEMBL7368755 | 0.77 | NPC1 (0.33) | NPC1 | |
| SCHEMBL7299455 | 0.77 | CCNC (0.40) | — | |
| SCHEMBL7293261 | 0.77 | CCNC (0.33) | KDM4EALDH1A1 | |
| SCHEMBL7372663 | 0.76 | NPC1 (0.34) | NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0308792-B1 | AZACHROMANE DERIVATIVES | MERCK PATENT GmbH (DE) | 1993-07-28 | — | — | EP | disclosed |
| US-4931454-A | Azachroman derivatives with effects on the cardiovascular system | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-06-05 | — | — | US | disclosed |
| EP-0308792-A2 | Azachromane derivatives | MERCK PATENT GmbH (DE) | 1989-03-29 | — | — | EP | disclosed |