SCHEMBL7290180

SCHEMBL7290180

CCOC(=O)C=CC1CCSCC1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 1/20 0.44
L3MBTL1 Q9Y468 3/20 0.39
TDP1 Q9NUW8 1/20 0.38
MAPT P10636 3/20 0.38
CA12 O43570 1/20 0.36
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36
CA7 P43166 1/20 0.36
CA9 Q16790 1/20 0.36
CA14 Q9ULX7 1/20 0.36
NPSR1 Q6W5P4 1/20 0.35
ALDH1A1 P00352 2/20 0.34
LMNA P02545 3/20 0.33
TTR P02766 1/20 0.33
DPP4 P27487 1/20 0.33
KDM4E B2RXH2 1/20 0.33
ESR2 Q92731 1/20 0.33
HTT P42858 1/20 0.33
ATM Q13315 1/20 0.32
MEN1 O00255 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7290177 1.00 HCAR2 (0.44) HCAR2L3MBTL1TDP1MAPTCA12
SCHEMBL10818379 0.89 HCAR2 (0.41) HCAR2L3MBTL1TDP1MAPTCA12
SCHEMBL7512241 0.87 HCAR2 (0.52) HCAR2L3MBTL1TDP1MAPTCA12
SCHEMBL18828565 0.87 HCAR2 (0.52) HCAR2L3MBTL1TDP1MAPTCA12
SCHEMBL7512242 0.87 HCAR2 (0.52) HCAR2L3MBTL1TDP1MAPTCA12
SCHEMBL9585760 0.87 HCAR2 (0.47) HCAR2L3MBTL1MAPTNPSR1ATM
SCHEMBL9586310 0.84 ATM (0.56) HCAR2MAPTNPSR1ALDH1A1ATM
SCHEMBL1126534 0.84 HCAR2 (0.48) HCAR2L3MBTL1TDP1MAPTCA12
SCHEMBL1126533 0.84 HCAR2 (0.48) HCAR2L3MBTL1TDP1MAPTCA12
SCHEMBL425748 0.84 HCAR2 (0.48) HCAR2L3MBTL1TDP1MAPTCA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5221753-A PREPARATION OF 1-(4-TETRAHYDROPYRANYL)- OR 1-(4-TETRAHYDROTHIOPYRANYL)PROP-1-EN-3-ONES BASF AKTIENGESELLSCHAFT (DE) 1993-06-22 US disclosed
US-4739066-A HYPOTENSIVE AGENTS, ANGIOTENSIN INHIBITORS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1988-04-19 US disclosed
US-4638000-A HYPOTENSIVES, ANGIOTENSIN INHIBITORS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1987-01-20 US disclosed
US-4591458-A ENZYME INHIBITORS; HYPOTENSIVE AGENTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1986-05-27 US disclosed
US-4548932-A ANGIOTENSIN INHIBITOR, HYPOTENSIVE AGENT TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1985-10-22 US disclosed
EP-0156455-A2 Condensed seven-membered ring compounds, their production and use Takeda Chemical Industries, Ltd. (JP) 1985-10-02 EP disclosed
EP-0135349-A1 Condensed seven-membered ring compounds and their production and use Takeda Chemical Industries, Ltd. (JP) 1985-03-27 EP disclosed