Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.56 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.56 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.56 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7280221 | 0.89 | PDE5A (0.70) | PDE5ATBXAS1PDE3BPDE3APTGS1 | |
| SCHEMBL7279816 | 0.88 | PDE5A (0.59) | PDE5ATBXAS1PDE3BPDE3APTGS1 | |
| SCHEMBL7289552 | 0.88 | PDE5A (0.56) | PDE5ATBXAS1PDE3BPDE3APTGS1 | |
| SCHEMBL7278005 | 0.88 | PDE5A (0.71) | PDE5ATBXAS1PDE3BPDE3APTGS1 | |
| SCHEMBL7280843 | 0.87 | PDE5A (0.71) | PDE5ATBXAS1PDE3BPDE3APTGS1 | |
| SCHEMBL7278130 | 0.87 | PDE5A (0.75) | PDE5ATBXAS1PDE3BPDE3APTGS1 | |
| SCHEMBL7277884 | 0.87 | PDE5A (0.57) | PDE5ATBXAS1PDE3BPDE3APTGS1 | |
| SCHEMBL7279350 | 0.85 | PDE5A (0.58) | PDE5ATBXAS1PDE3BPDE3APTGS1 | |
| SCHEMBL7280766 | 0.85 | PDE5A (0.51) | PDE5ATBXAS1PDE3BPDE3APTGS1 | |
| SCHEMBL7280247 | 0.84 | PDE5A (0.60) | PDE5ATBXAS1PDE3BPDE3APTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579496-B1 | 4-Aminoquinazoline derivatives, and their use as medicine | ONO PHARMACEUTICAL CO (JP) | 2001-11-14 | — | — | EP | disclosed |
| EP-0579496-A1 | 4-Aminoquinazoline derivatives, and their use as medicine | ONO PHARMACEUTICAL CO., LTD. (JP) | 1994-01-19 | — | — | EP | disclosed |