Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.42 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8350121 | 0.92 | HTT (0.53) | TSHRCYP3A4HTTKDM4EMAPT | |
| SCHEMBL7283539 | 0.87 | TSHR (0.45) | TSHRCYP3A4HTTKDM4EMAPT | |
| SCHEMBL7290123 | 0.85 | TSHR (0.50) | TSHRCYP3A4HTTKDM4EMAPT | |
| SCHEMBL7291210 | 0.84 | TSHR (0.49) | TSHRCYP3A4HTTKDM4EMAPT | |
| SCHEMBL8349172 | 0.80 | HTT (0.50) | TSHRCYP3A4HTTKDM4EMAPT | |
| SCHEMBL7291215 | 0.80 | TSHR (0.50) | TSHRCYP3A4HTTKDM4EMAPT | |
| SCHEMBL8347879 | 0.80 | KDM4E (0.68) | TSHRKDM4EMAPTMEN1KMT2A | |
| SCHEMBL7291085 | 0.79 | KDM4E (0.66) | TSHRCYP3A4KDM4EMAPTALDH1A1 | |
| SCHEMBL7293064 | 0.79 | KDM4E (0.66) | TSHRCYP3A4KDM4EMAPTALDH1A1 | |
| SCHEMBL10733777 | 0.78 | TSHR (0.55) | TSHRCYP3A4KDM4EMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0343574-B1 | 4(1H)-quinolone derivatives | KIRIN BREWERY (JP) | 1994-07-27 | — | — | EP | disclosed |
| US-5081121-A | Cardiotonic agents | KIRIN BEER KABUSHIKI KAISHA (JP) | 1992-01-14 | — | — | US | disclosed |
| EP-0343574-A1 | 4(1H)-quinolone derivatives | KIRIN BEER KABUSHIKI KAISHA (JP) | 1989-11-29 | — | — | EP | disclosed |