Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.52 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MGLL | Q99685 | 2/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7284783 | 1.00 | TDP1 (0.60) | TDP1MAPTRXFP1FFAR1LPAR1 | |
| SCHEMBL7284943 | 0.98 | TDP1 (0.62) | TDP1MAPTRXFP1FFAR1LPAR1 | |
| SCHEMBL1087411 | 0.94 | TDP1 (0.60) | TDP1MAPTRXFP1FFAR1LPAR1 | |
| SCHEMBL12446327 | 0.94 | TDP1 (0.64) | TDP1FFAR1LMNAALOX5HDAC1 | |
| SCHEMBL1788500 | 0.94 | TDP1 (0.68) | TDP1MAPTRXFP1FFAR1LPAR1 | |
| SCHEMBL7781081 | 0.94 | TDP1 (0.68) | TDP1MAPTRXFP1FFAR1LPAR1 | |
| SCHEMBL28587263 | 0.89 | MAPT (0.72) | TDP1MAPTRXFP1FFAR1LPAR1 | |
| SCHEMBL28574865 | 0.89 | MAPT (0.72) | TDP1MAPTRXFP1FFAR1LPAR1 | |
| SCHEMBL1681599 | 0.89 | MAPT (0.72) | TDP1MAPTRXFP1FFAR1LPAR1 | |
| SCHEMBL1788501 | 0.89 | MAPT (0.72) | TDP1MAPTRXFP1FFAR1LPAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4760064-A | Cardiotonic agent | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-07-26 | — | — | US | disclosed |
| EP-0187322-A1 | Carbostyril compounds, compositions containing same and processes for preparing same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-07-16 | — | — | EP | disclosed |