⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1659784 | 1.00 | — | — | |
| SCHEMBL12860125 | 0.92 | FUCA1 (0.43) | — | |
| SCHEMBL771194 | 0.85 | — | — | |
| SCHEMBL19259395 | 0.85 | — | — | |
| SCHEMBL24477654 | 0.85 | — | — | |
| SCHEMBL24477647 | 0.85 | — | — | |
| SCHEMBL19259391 | 0.85 | — | — | |
| SCHEMBL4056873 | 0.82 | CA1 (0.50) | — | |
| SCHEMBL2307684 | 0.82 | CA1 (0.36) | — | |
| SCHEMBL358719 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9937186-B2 | Sulfonamides derived from tricyclyl-2-aminocycloalkanols as anticancer agents | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2018-04-10 | — | — | US | disclosed |
| US-20170015625-A1 | SULFONAMIDES DERIVED FROM TRICYCLYL-2-AMINOCYCLOALKANOLS AS ANTICANCER AGENTS | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2017-01-19 | — | — | US | disclosed |
| US-5442044-A | Hypotensive agents | PFIZER INC. (US) | 1995-08-15 | — | — | US | disclosed |
| EP-0661292-A1 | Orally active renin inhibitors | PFIZER INC. (US) | 1995-07-05 | — | — | EP | disclosed |
| EP-0438233-A2 | Orally active renin inhibitors | PFIZER INC. (US) | 1991-07-24 | — | — | EP | disclosed |