Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.55 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | DHODH | Q02127 | 1/20 | 0.47 |
| ▸ | DHPS | P49366 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1687866 | 0.84 | NR1H4 (0.67) | NR1H4TRPV1HDAC3HDAC11HDAC8 | |
| SCHEMBL1496348 | 0.82 | CA12 (0.58) | NR1H4TRPV1HDAC3HDAC11HDAC8 | |
| SCHEMBL4721074 | 0.80 | NR1H4 (0.58) | NR1H4TRPV1HDAC3HDAC11HDAC8 | |
| SCHEMBL1687867 | 0.78 | NPC1 (0.79) | NR1H4TRPV1HDAC3HDAC11HDAC8 | |
| SCHEMBL7293746 | 0.78 | NPC1 (0.79) | NR1H4TRPV1HDAC3HDAC11HDAC8 | |
| SCHEMBL7291713 | 0.78 | NPC1 (0.79) | NR1H4TRPV1HDAC3HDAC11HDAC8 | |
| SCHEMBL25348875 | 0.75 | P2RX1 (0.63) | NR1H4TRPV1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL9284694 | 0.75 | CFTR (0.63) | NR1H4TRPV1HDAC3HDAC11HDAC8 | |
| SCHEMBL11759876 | 0.75 | KCNK3 (0.59) | NR1H4HDAC3HDAC8HDAC6SMN1; SMN2 | |
| SCHEMBL12585027 | 0.74 | MAPT (0.71) | NR1H4TRPV1HDAC3HDAC11HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0358118-B1 | Phenylamides - process for their preparation as well as a drug containing those compounds | BOEHRINGER MANNHEIM GMBH (DE) | 1994-03-16 | — | — | EP | disclosed |
| EP-0358118-A1 | Phenylamides - process for their preparation as well as a drug containing those compounds | Roche Diagnostics GmbH (DE) | 1990-03-14 | — | — | EP | disclosed |