Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.73 |
| ▸ | IGF1R | P08069 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.44 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8810012 | 0.88 | ADORA1 (0.73) | ADORA1IGF1RMAPK1MAPK14MAPK3 | |
| SCHEMBL7299166 | 0.88 | ADORA1 (0.77) | ADORA1IGF1RMAPK1MAPK14MAPK3 | |
| SCHEMBL8807841 | 0.87 | ADORA1 (0.77) | ADORA1IGF1RMAPK1MAPK14MAPK3 | |
| SCHEMBL8807266 | 0.86 | ADORA1 (0.88) | ADORA1IGF1RMAPK1AKT1KDM4E | |
| SCHEMBL8808692 | 0.86 | ADORA1 (0.80) | ADORA1IGF1RMAPK1MAPK14MAPK3 | |
| SCHEMBL7292709 | 0.85 | ADORA1 (0.69) | ADORA1IGF1RMAPK1MAPK14MAPK3 | |
| SCHEMBL7294123 | 0.85 | ADORA1 (0.79) | ADORA1IGF1RMAPK1MAPK14MAPK3 | |
| SCHEMBL7304113 | 0.85 | ADORA1 (0.68) | ADORA1IGF1RMAPK1MEN1KMT2A | |
| SCHEMBL7290705 | 0.84 | ADORA1 (0.74) | ADORA1IGF1RMAPK1MAPK14MAPK3 | |
| SCHEMBL7301601 | 0.84 | ADORA1 (0.74) | ADORA1IGF1RMAPK1MAPK14MAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497258-B1 | Use of adenosine antagonists in the prevention and treatment of pancreatitis and ulcer | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-01-02 | — | — | EP | disclosed |
| EP-0467248-B1 | Pyrazolopyridine compound and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1998-10-28 | — | — | EP | disclosed |
| US-5338743-A | Pancreatitis | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-08-16 | — | — | US | disclosed |
| US-5204346-A | Cognition activators; analgesics; antidepressants; vasodilation; cardiovascular and urogential disorders; | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-04-20 | — | — | US | disclosed |
| EP-0497258-A2 | Use of adenosine antagonists in the prevention and treatment of pancreatitis and ulcer | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-08-05 | — | — | EP | disclosed |
| EP-0467248-A2 | Pyrazolopyridine compound and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-01-22 | — | — | EP | disclosed |