Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 10/20 | 0.77 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.77 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.77 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.77 |
| ▸ | MTOR | P42345 | 2/20 | 0.77 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.77 |
| ▸ | CLK1 | P49759 | 2/20 | 0.77 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.77 |
| ▸ | GAK | O14976 | 1/20 | 0.77 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.77 |
| ▸ | STK10 | O94804 | 1/20 | 0.77 |
| ▸ | PIM1 | P11309 | 1/20 | 0.77 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.77 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.77 |
| ▸ | CLK2 | P49760 | 1/20 | 0.77 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.77 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.77 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.77 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.77 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL729541 | 1.00 | PIK3CA (0.77) | PIK3CAPIK3CDCSNK2A2PIK3CBMTOR | |
| Gsk-1059615 SCHEMBL29351551 | 0.88 | PIK3CA (1.00) | PIK3CAPIK3CDCSNK2A2PIK3CBMTOR | |
| Gsk-1059615 SCHEMBL29381321 | 0.88 | PIK3CA (1.00) | PIK3CAPIK3CDCSNK2A2PIK3CBMTOR | |
| Gsk-1059615 SCHEMBL1805561 | 0.88 | PIK3CA (1.00) | PIK3CAPIK3CDCSNK2A2PIK3CBMTOR | |
| Gsk-1059615 SCHEMBL1805560 | 0.88 | PIK3CA (1.00) | PIK3CAPIK3CDCSNK2A2PIK3CBMTOR | |
| Gsk-1059615 SCHEMBL1805557 | 0.88 | PIK3CA (1.00) | PIK3CAPIK3CDCSNK2A2PIK3CBMTOR | |
| SCHEMBL4396728 | 0.80 | PIK3CA (0.77) | PIK3CAPIK3CDCSNK2A2PIK3CBMTOR | |
| SCHEMBL4396725 | 0.80 | PIK3CA (0.77) | PIK3CAPIK3CDCSNK2A2PIK3CBMTOR | |
| SCHEMBL4402070 | 0.77 | PIM1 (0.72) | PIK3CAPIK3CDCSNK2A2PIK3CBMTOR | |
| SCHEMBL4402072 | 0.77 | PIM1 (0.72) | PIK3CAPIK3CDCSNK2A2PIK3CBMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140296224-A1 | QUINOLINE DERIVATIVES AS PI3 KINASE INHIBITORS | GLAXOSMITHKLINE LLC | 2014-10-02 | — | — | US | claimed |
| US-8404837-B2 | Quinoline derivatives as P13 kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2013-03-26 | — | — | US | claimed |
| EP-2596793-B1 | Quinoline derivatives as PI3 kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2015-07-08 | — | — | EP | disclosed |
| US-20140296224-A1 | QUINOLINE DERIVATIVES AS PI3 KINASE INHIBITORS | GLAXOSMITHKLINE LLC | 2014-10-02 | — | — | US | disclosed |
| US-8785433-B2 | Quinoline derivatives as PI3 kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2014-07-22 | — | — | US | disclosed |
| US-20140100234-A1 | QUINOLINE DERIVATIVES AS PI3 KINASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-04-10 | — | — | US | disclosed |
| US-8633187-B2 | Quinoline derivatives as PI3 kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2014-01-21 | — | — | US | disclosed |
| EP-2596793-A1 | Quinoline derivatives as PI3 kinase inhibitors | Glaxosmithkline LLC (US) | 2013-05-29 | — | — | EP | disclosed |
| US-8404837-B2 | Quinoline derivatives as P13 kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2013-03-26 | — | — | US | disclosed |
| US-20120165321-A1 | QUINOLINE DERIVATIVES AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION | 2012-06-28 | — | — | US | disclosed |
| US-8138347-B2 | Quinoline derivatives as PI3 kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2012-03-20 | — | — | US | disclosed |
| US-20100168100-A1 | QUINOLINE DERIVATIVES AS P13 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2010-07-01 | — | — | US | disclosed |
| US-20100152112-A1 | QUINOLINE DERIVATIVES AS P13 KINASE INHIBITORS | GLAXOSMITHKLINE LLC | 2010-06-17 | — | — | US | disclosed |
| EP-2192902-A1 | QUINOLINE DERIVATIVES AS P13 KINASE INHIBITORS | GlaxoSmithKline LLC (US) | 2010-06-09 | — | — | EP | disclosed |
| US-20080300239-A1 | QUINOLINE DERIVATIVES AS PI3 KINASE INHIBITORS | GLAXOSMITHKLINE LLC | 2008-12-04 | — | — | US | disclosed |
| WO-2008144464-A1 | QUINOLINE DERIVATIVES AS P13 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-11-27 | — | — | WO | disclosed |
| WO-2008144463-A1 | QUINOLINE DERIVATIVES AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-11-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152112-A1 | QUINOLINE DERIVATIVES AS P13 KINASE INHIBITORS | JAK3, PI4KA, PIP4K2A | PIK3CA 13/4885PIK3CD 4/4885CSNK2A2 1600/4885 |
| US-20140100234-A1 | QUINOLINE DERIVATIVES AS PI3 KINASE INHIBITORS | PIK3CD, PIK3CG, PIK3CB | PIK3CA 6/4885PIK3CD 1/4885CSNK2A2 1838/4885 |
| US-20100168100-A1 | QUINOLINE DERIVATIVES AS P13 KINASE INHIBITORS | JAK3, PI4KA, PIP4K2A | PIK3CA 13/4885PIK3CD 4/4885CSNK2A2 1600/4885 |
| US-20120165321-A1 | QUINOLINE DERIVATIVES AS PI3 KINASE INHIBITORS | PIK3CD, PIK3CG, PIK3CB | PIK3CA 6/4885PIK3CD 1/4885CSNK2A2 1838/4885 |
| US-20140296224-A1 | QUINOLINE DERIVATIVES AS PI3 KINASE INHIBITORS | PIK3CD, PIK3CG, PIK3CB | PIK3CA 6/4885PIK3CD 1/4885CSNK2A2 1838/4885 |
| US-20080300239-A1 | QUINOLINE DERIVATIVES AS PI3 KINASE INHIBITORS | PIK3CD, PIK3CG, PIK3CB | PIK3CA 6/4885PIK3CD 1/4885CSNK2A2 1838/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.