Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 7/20 | 0.55 |
| ▸ | MVD | P53602 | 2/20 | 0.46 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | REN | P00797 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2444893 | 0.97 | ACE (0.55) | ACEMVDRAB9ARENCHRM2 | |
| SCHEMBL7297993 | 0.96 | ACE (0.54) | ACEMVDRAB9ARENCHRM2 | |
| SCHEMBL6794104 | 0.87 | ACE (0.68) | ACEMVDACE2REN | |
| SCHEMBL7299197 | 0.87 | ACE (0.68) | ACEMVDACE2REN | |
| SCHEMBL6794095 | 0.87 | ACE (0.68) | ACEMVDACE2REN | |
| Miridesap SCHEMBL1537496 | 0.84 | ACE (0.68) | ACEMVDRENCHRM2CHRM4 | |
| Miridesap SCHEMBL1685022 | 0.84 | ACE (0.68) | ACEMVDRENCHRM2CHRM4 | |
| Miridesap SCHEMBL6788714 | 0.84 | ACE (0.68) | ACEMVDRENCHRM2CHRM4 | |
| Miridesap SCHEMBL1537499 | 0.84 | ACE (0.68) | ACEMVDRENCHRM2CHRM4 | |
| SCHEMBL11559923 | 0.83 | ACE (0.62) | ACEMVDACE2REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915088-B1 | D-Proline derivatives | HOFFMANN LA ROCHE (CH) | 2002-09-18 | — | — | EP | claimed |