Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD3 | O94806 | 2/20 | 0.41 |
| ▸ | PRKCG | P05129 | 2/20 | 0.41 |
| ▸ | PRKCB | P05771 | 2/20 | 0.41 |
| ▸ | PRKCA | P17252 | 2/20 | 0.41 |
| ▸ | PRKCH | P24723 | 2/20 | 0.41 |
| ▸ | PRKCI | P41743 | 2/20 | 0.41 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.41 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.41 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.41 |
| ▸ | LPAR1 | Q92633 | 7/20 | 0.40 |
| ▸ | LPAR3 | Q9UBY5 | 7/20 | 0.40 |
| ▸ | LPAR6 | P43657 | 3/20 | 0.40 |
| ▸ | LPAR4 | Q99677 | 3/20 | 0.40 |
| ▸ | LPAR5 | Q9H1C0 | 3/20 | 0.40 |
| ▸ | LPAR2 | Q9HBW0 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9999967 | 1.00 | PRKD3 (0.41) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL12883075 | 0.97 | PRKD3 (0.40) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL28278162 | 0.88 | PRKD3 (0.38) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL27339947 | 0.88 | PRKD3 (0.38) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL16406021 | 0.88 | PRKD3 (0.46) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL27466717 | 0.85 | PRKD3 (0.39) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL19067480 | 0.84 | CYP2C9 (0.39) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL12655009 | 0.83 | PRKD3 (0.34) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL27730572 | 0.83 | PRKD3 (0.42) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL6995710 | 0.82 | LPAR1 (0.38) | LPAR1LPAR3LPAR6LPAR4LPAR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5270464-A | Anti-HIV-1 tetrahydroimidazo[1,4]benzodiazepin-2-(thi) ones | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-12-14 | — | — | US | disclosed |
| EP-0453042-A1 | Novel 2,9-disubstituted-4H-pyrido-[1,2-a]pyrimidin-4-ones | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-10-23 | — | — | EP | disclosed |