Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 12/20 | 0.45 |
| ▸ | F10 | P00742 | 2/20 | 0.42 |
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | PLAT | P00750 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7304106 | 0.94 | ACACB (0.46) | ACACBF2F10PLGPLAT | |
| SCHEMBL7303910 | 0.91 | ACACB (0.43) | ACACBF2F10PLGPLAT | |
| SCHEMBL7324356 | 0.88 | F10 (0.47) | ACACBF2F10 | |
| SCHEMBL8717200 | 0.88 | F2 (0.49) | F2F10PLGPLATPRSS1 | |
| SCHEMBL7302360 | 0.86 | ACACB (0.45) | ACACBF2F10PLGPLAT | |
| SCHEMBL7305031 | 0.86 | F2 (0.43) | ACACBF2F10PLGPLAT | |
| SCHEMBL7305037 | 0.84 | F2 (0.42) | ACACBF2F10PLGPLAT | |
| SCHEMBL7324374 | 0.84 | F2 (0.41) | ACACBF2F10PLGPLAT | |
| SCHEMBL7332989 | 0.83 | F2 (0.47) | ACACBF2F10PLGPLAT | |
| SCHEMBL7332615 | 0.83 | F2 (0.49) | F2F10PLGPLATPRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0559046-B1 | N-amidinopiperidinyl(3/4)- or N-amidino-1,4-Oxazinyl(2)-substituted sulfonamides, process for their preparation and use as thrombin inhibitors | HOFFMANN LA ROCHE (CH) | 2001-07-11 | — | — | EP | disclosed |
| EP-0559046-A1 | N-amidinopiperidinyl(3/4)- or N-amidino-1,4-Oxazinyl(2)-substituted sulfonamides, process for their preparation and use as thrombin inhibitors | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1993-09-08 | — | — | EP | disclosed |