Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9844135 | 1.00 | GRM2 (0.64) | GRM2SIGMAR1 | |
| SCHEMBL8798938 | 0.93 | GRM2 (0.68) | GRM2SIGMAR1 | |
| SCHEMBL1712583 | 0.88 | GRM2 (0.53) | GRM2 | |
| SCHEMBL1712585 | 0.88 | GRM2 (0.53) | GRM2 | |
| SCHEMBL1223893 | 0.88 | GRM2 (0.65) | GRM2SIGMAR1 | |
| SCHEMBL7291016 | 0.88 | GRM2 (0.65) | GRM2SIGMAR1 | |
| SCHEMBL1223892 | 0.88 | GRM2 (0.65) | GRM2SIGMAR1 | |
| SCHEMBL7298934 | 0.87 | GRM2 (0.61) | GRM2SIGMAR1 | |
| SCHEMBL7300334 | 0.87 | GRM2 (0.61) | GRM2SIGMAR1 | |
| SCHEMBL7291394 | 0.85 | GRM2 (0.47) | GRM2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0635505-B1 | 4-Aryloxy- and 4-arylthiopiperidine derivatives | MERCK PATENT GMBH (DE) | 1997-10-15 | — | — | EP | disclosed |
| US-5561145-A | 4-aryloxy- and 4-arylthiopiperidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESHRANKTER HAFTUNG (DE) | 1996-10-01 | — | — | US | disclosed |
| EP-0459256-B1 | Oxazolidinones with CNS-depressant activity | MERCK PATENT GMBH (DE) | 1995-07-12 | — | — | EP | disclosed |
| EP-0635505-A1 | 4-Aryloxy- and 4-arylthiopiperidine derivatives | MERCK PATENT GmbH (DE) | 1995-01-25 | — | — | EP | disclosed |
| US-5232931-A | OXAZOLIDINONES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-08-03 | — | — | US | disclosed |
| EP-0459256-A1 | Oxazolidinones with CNS-depressant activity | MERCK PATENT GmbH (DE) | 1991-12-04 | — | — | EP | disclosed |
| EP-0443197-A2 | Oxazolidinones | MERCK PATENT GmbH (DE) | 1991-08-28 | — | — | EP | disclosed |