Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6988508 | 1.00 | HPGD (0.51) | HPGDGPR119RECQLEPHX1USP2 | |
| SCHEMBL2566080 | 0.93 | HPGD (0.54) | HPGDGPR119RECQLEPHX1USP2 | |
| SCHEMBL3955730 | 0.91 | HPGD (0.52) | HPGDGPR119RECQLEPHX1USP2 | |
| SCHEMBL13219346 | 0.87 | HPGD (0.51) | HPGDGPR119RECQLEPHX1USP2 | |
| SCHEMBL17392565 | 0.87 | HPGD (0.51) | HPGDGPR119RECQLEPHX1USP2 | |
| SCHEMBL65675 | 0.87 | HPGD (0.51) | HPGDGPR119RECQLEPHX1USP2 | |
| SCHEMBL690145 | 0.86 | NR1H2 (0.50) | HPGDGPR119RECQLEPHX1USP2 | |
| SCHEMBL9836659 | 0.86 | HPGD (0.50) | HPGDGPR119RECQLEPHX1USP2 | |
| SCHEMBL21938019 | 0.86 | HPGD (0.50) | HPGDGPR119RECQLEPHX1USP2 | |
| SCHEMBL2526467 | 0.86 | HPGD (0.50) | HPGDGPR119RECQLEPHX1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445796-B1 | Derivatives of acetic acid containing peptide bonds | HOFFMANN LA ROCHE (CH) | 1998-06-17 | — | — | EP | disclosed |
| EP-0445796-A2 | Derivatives of acetic acid | F. HOFFMANN-LA ROCHE AG (CH) | 1991-09-11 | — | — | EP | disclosed |